Incidence of Residual Neuromuscular Blockade in Patients With Frailty Undergoing Gynecologic Cancer Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 622
- 试验地点
- 2
- 主要终点
- Incidence of residual neuromuscular blockade
研究概览
简要总结
Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital length of stay. Our focus centers on investigating the frailty index in the context of complications experienced by patients undergoing oncologic gynecology surgery. The principal objective of this research is to elucidate the extent to which residual neuromuscular blocking agents are linked to frailty.
详细描述
Among patients undergoing oncologic gynecological procedures, such as those for vulvar cancer, endometrial cancer, and ovarian cancer, the incidence of frailty has been observed to range from 14% to 45%. Frailty directly influences the metabolism of anesthetic agents and intraoperative management. Furthermore, the prevalence of residual neuromuscular blocking agents following surgery can be as high as 26% to 53%. No prior research has investigated the correlation between residual muscle relaxants and frailty in gynecologic oncology patients. This study is designed to assess the prevalence of residual muscle relaxants in these patients with frailty. Additionally, data on the incidence of frailty and its impact on postoperative outcomes and prognosis in patients undergoing gynecologic oncology surgery will be collected and reported.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age >,= 18 years
- •Patients undergoing elective gynecologic-oncology surgery
排除标准
- •Unable to communicate Thai
- •Unable to understand the questionnaire
- •Preexisting neuromuscular disease
- •Preexisting disease involved wrist that may affect the nerve stimulator examination
结局指标
主要结局
Incidence of residual neuromuscular blockade
时间窗: 0-30 minute after surgery
Incidence of residual neuromuscular blockade with the relation of frailty after gynecologic oncology surgery
Incidence of frailty
时间窗: 0 - 24 hours preoperative
Incidence of frailty in patients undergoing gynecologic oncology surgery
次要结局
- Anesthetic technique used(Throughout Intraoperative period, an average 3-5 hours)
- Rate of blood transfusion(Throughout Intraoperative period, an average 3-5 hours to 24 hours postoperative)
- Rate of vasopressor usage(Throughout Intraoperative period, an average 3-5 hours to 24 hours postoperative)
- Length of hospital stay(Through study completion, an average of 1 year, an average 3 - 5 days)
- Mortality rate(30 days after operation)
- Rate of intensive care unit admission(0 - 24 hours postoperative)
- Rate of re-intubation(0 - 24 hours postoperative)
- Rate of postoperative mechanical ventilation(0 - 24 hours postoperative)
- Rate of postoperative pulmonary complications(3 days after operation)