Functional studies in different forms of hyperkinetic movement disorders - Functional studies in hyperkinetic movement disorders

Academisch Medisch Centrum0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年5月13日

试验速览

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•Group 1: Psychogenic movement disorders: We will include patients with *clinically established psychogenic movement disorders*, as defined by Hinson and colleagues and Williams and colleagues . This means movements incongruent with organic disease or inconsistent symptoms, in addition to the presence of other false neurological signs or multiple somatisations.
•Group 2 : Gilles de la Tourette: DSM-IV diagnosis plus jerky movements of limbs.
•Group 3: MD patients with proven DYT 11 mutation and DYT11 negative MD patients (the latter for EMG-fMRI only).
•All patients should have jerky movements frequently.

•General exclusion criteria are neurological co-morbidity and the use of substance and/or medication that may influence study results. For the fMRI-EMG study extra exclusion criteria apply. Participants should not have metal implants (e.g. pacemaker), nor should they be pregnant. Moreover, participants with claustrofobia are excluded from fMRI investigation.

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