ISRCTN24742183已完成2 期
A randomised feasibility study of extended chemotherapy with neoadjuvant carboplatin, then surgery followed by adjuvant paclitaxel and gemcitabine versus neoadjuvant gemcitabine and carboplatin, then surgery, followed by adjuvant paclitaxel for women with epithelial non-mucinous advanced inoperable peritoneal malignancy
niversity of Warwick (UK)0 个研究点目标入组 88 人开始时间: 2006年12月14日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 88
研究概览
简要总结
2017 abstract in: https://doi.org/10.1200/jco.2012.30.15_suppl.5046
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •1. Clinical, radiological, histological and findings consistent with a diagnosis of International Federation of Gynecology and Obstetrics (FIGO) stage 3C/4 primary epithelial ovarian cancer, primary peritoneal carcinoma, ovarian carcinosarcoma, or fallopian tube carcinoma
- •2. Patients (aged 18 - 75 years) will be unsuitable for primary debulking surgery as defined by laparoscopic staging procedures, supplemented by clinical and radiological assessments
- •3. Eastern Cooperative Oncology Group (ECOG) performance status zero, one, two or three
排除标准
- •1. Prior malignancy, chemotherapy or radiotherapy
- •2. Known brain metastases
- •3. Poorly controlled potentially serious medical conditions likely to render treatment compliance with the protocol difficult
- •4. Those of child-bearing potential not employing adequate contraception, which may include prescription contraceptives
研究者
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