A clinical study on the prevention and treatment of peripheral neurotoxicity of oxaliplatin by Danggui Sini granule

Jiangsu Province Hospital on Integration Chinese and Western Medicine0 个研究点开始时间: 待定最近更新: 2023年2月20日

试验速览

暂无简介。

•1. All the selected cases were in accordance with the diagnostic criteria of colorectal cancer and were confirmed by pathology or cytology with stage II-IV;
•2. Karnofsky score above 60, the predicted survival time was more than 4 months;
•3. Aged 18-80 years;
•4. No severe damage to the center of gravity, liver, kidney or hematopoietic system;
•5. Volunteer to participate in clinical research and sign the informed consent.

•1. with any grade of peripheral neuropathy;
•2. Having received chemotherapy drugs with neurotoxicity in one month, such as oxaliplatin, cisplatin, taxanes or vinblastine alkaloids;
•3. We are receiving carbamazepine, phenytoin sodium, valproate sodium, gabapentin, pregabalin, venlafaxine, norvenlafaxine, minapram, duloxetine, tricyclic antidepressants and other drugs that may have therapeutic or preventive effects on neuropathy;
•4. A history of second or third degree atrioventricular block;
•5. Participate in any other clinical study of preventing and treating neurotoxicity;
•6. There is a family history of hereditary/familial neuropathy;
•7. Patients with severe infection;
•8. Patients with mental illness;
•9. Pregnant women.

发起方

Jiangsu Province Hospital on Integration Chinese and Western Medicine