Changes Induced by Bariatric Surgery in Cardiovascular Responses to Dietary Supplementation With Sodium Nitrate
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Assess changes in s-nitrosothiols
研究概览
简要总结
Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway. This is due to the reduction of nitrate to nitrite by the action of bacteria in the mouth and the reduction of nitrite to NO depending on the acidic pH on the stomach or by enzymes with nitrite-reductase activity. The acidic environment of the stomach is very important to the formation of NO and S-nitrosothiols and several studies suggest that changes in gastric pH can affect this conversion. In this context, bariatric surgery, by altering the anatomy of the stomach and increasing gastric pH, can affect the nitrate-nitrite-NO pathway and change the antihypertensive and antioxidant effect of sodium nitrate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •For volunteers who underwent bariatric surgery:
- •Age over 18 years old and under 60 years old;
- •Having had bariatric surgery more than 1 and a half years ago;
- •Present stabilized weight loss;
- •For voluntary controls:
- •Age over 18 years old and under 60 years old;
排除标准
- •For volunteers who underwent bariatric surgery and controls:
- •Having uncontrolled blood pressure (above 160/100 mmHg), even with use regulate up to two antihypertensive agents;
- •Hypertensive patients must be using a maximum of two antihypertensives;
- •Have Diabetes Mellitus or other endocrinopathy;
- •Have kidney or liver failure;
- •Individuals who smoke.
结局指标
主要结局
Assess changes in s-nitrosothiols
时间窗: 14 days
Change in s-nitrosothiols concentration in plasma After Sodium Nitrate Treatment
次要结局
- Assess changes in Vascular stiffness(14 days)
- Assess changes in blood pressure(14 days)
- Assess changes in nitrate concentration(14 days)
- Assess changes in nitrite concentration(14 days)
- Assess changes in endotelial function(14 days)
研究者
Jéssica Maria Sanches Lopes
PhD in Pharmacology
University of Sao Paulo