The Effects of Inorganic Nitrite on cardiac and skeletal muscle: Physiology, Pharmacology and Therapeutic Potential. Peripheral Arterial Disease - Effects of Inorganic Nitrite on skeletal muscle: PAD

niversity of Aberdeen0 个研究点目标入组 132 人开始时间: 2012年4月13日最近更新: 2019年2月28日

适应症

试验速览

暂无简介。

•Patients with stable intermittent claudication 1) of at least 3 months duration 2) with clinical findings of peripheral vascular disease and 3) an ABPI<0.9.
•Strict attention will be paid to secondary prevention measures and patients will be advised to exercise regularly. Patients will not be offered supervised exercise therapy. Dietary nitrite/nitrate intake will be assessed via a short questionnaire. Patients with a high dietary intake will not be excluded from the study as we wish to assess the effects or oral sodium nitrate supplementation on platelet function irrespective if a patient’s diet.
•They should be able to walk for at least one minute on a treadmill using the Skinner-Gardner protocol and the variability in absolute claudication distance (ACD) between two consecutive baseline tests performed within a two week period should be less than 25%.
•Patients must be on a statin and aspirin for at least six weeks prior to being enrolled in this study. Patients on pentoxyifylline, cilostazol, or dietary supplements such as omega-3 fatty acids and l-arginine will require a 1 month washout period prior to enrolment.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 132
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 132

•Patients with the following will be excluded:
•rest pain or ulceration
•recent arterial revascularisation (within the past 3 months)
•other co-morbidities that may impede the patient’s ability to perform an exercise test (arthritis, severe coronary artery disease or chronic obstructive pulmonary disease)
•Patients on clopidogrel
•oral nitrate preparations

发起方

niversity of Aberdeen