NL-OMON49758已完成不适用
Acute effects of inorganic nitrate on brain insulin-sensitivity in abdominally obese men - Nitrate and brain insulin-sensitivity
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Aged between 18 - 60 years
- •- Waist circumference minimal 102 cm (abdominally obese)
- •- Fasting plasma glucose * 7.0 mmol/L
- •- Fasting serum total cholesterol * 8.0 mmol/L
- •- Systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg
- •- Stable body weight (weight gain or loss < 3 kg in the past three months)
- •- Willingness to give up being a blood donor from 8 weeks before the start of
- •the study, during the study and for 4 weeks after completion of the study
- •- Willingness not to use antibacterial mouth wash or toothpaste, chewing-gum
- •and tongue-scraping a week before the study
- •- No difficult venipuncture as evidenced during the screening visit
排除标准
- •- Left-handedness
- •- Current smoker, or smoking cessation < 12 months
- •- Diabetic patients
- •- Familial hypercholesterolemia
- •- Abuse of drugs
- •- More than 3 alcoholic consumptions per day
- •- Use of products or dietary supplements known to interfere with the main
- •outcomes as judged by the principal investigators
- •- Use medication to treat blood pressure, lipid or glucose metabolism
- •- Pharmacological treatment advised based on the Dutch general practitioners
- •association (NHG) for cardiovascular risk management.
- •- Use of an investigational product within another biomedical intervention
- •trial within the previous 1-month
- •- Severe medical conditions that might interfere with the study, such as
- •epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive
- •pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and
- •rheumatoid arthritis
- •- Active cardiovascular disease like congestive heart failure or
- •cardiovascular event, such as an acute myocardial infarction or cerebrovascular
- •- Specific contra-indications for MRI imaging, including pacemakers,
- •surgical clips/material in body, metal splinters in eye, claustrophobia, or
- •tattoos in the facial area, such as permanent make-up.
研究者
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