Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Reduction in myocardial infarction
研究概览
简要总结
Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%). Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. Human studies in cardiac patients have shown promising results with precondition. Instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm.
The investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with ruptured abdominal aortic aneurysm offered surgery
- •Age > 18 years
排除标准
- •Technical inoperable
研究组 & 干预措施
Control
No precondition
Precondition
Induction of precondition at start of operation on a arm
干预措施: Precondition (Procedure)
结局指标
主要结局
Reduction in myocardial infarction
时间窗: 4 to 5 years
次要结局
- Improvement in survival Description on inflammatory response(4 to 5 years)
研究者
Nikolaj Eldrup
MD PhD
Aarhus University Hospital
