跳至主要内容
临床试验/NCT01883674
NCT01883674已完成不适用

Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.

Université de Sherbrooke2 个研究点 分布在 1 个国家目标入组 41 人开始时间: 2012年5月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
41
试验地点
2
主要终点
Muscle mass

研究概览

简要总结

This project evaluates the use of different types of proteins from various food sources after an exercise session, on muscle mass and physical capacity in aged sarcopenic men (who have low muscle mass). Specifically, researchers want to:

  • Examine the efficiency of protein intake after exercise on muscle mass and physical abilities;
  • Examine the impact of exercise and proteins on blood lipids (LDL cholesterol, HDL cholesterol, total cholesterol and triglycerides);
  • Examine the impact of exercise and proteins on liver enzymes;
  • Examine the impact of exercise and proteins on a hormone that controls hunger;
  • Evaluate the program's impact on the ability of the body to produce energy.

All participants are exercising (resistance training) and ingest one of the 3 different sources of proteins, immediately after training:

  • Milk proteins (from milk beverage)
  • Essential amino acids (added to a soya beverage)
  • No protein (rice beverage - control group)

Our hypothesis is that proteins from milk will induce a gain in muscle mass and physical function equivalent to the essential amino acids (EAA). We anticipate that both milk proteins and EAA will be both superior to control group.

This would represent an interesting finding since milk is more accessible, palatable and cheaper than essential amino acids commercial mix.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
65 Years 至 75 Years(Older Adult)
性别
Male
接受健康志愿者

入选标准

  • 65-75 years
  • francophone or understanding French
  • muscle mass index < 10.75 kg/m2 (Janssen et al, 2004)
  • body mass index <30kg/m²
  • weight stable (< 2 kg) for 6 mo
  • no resistance exercise for 3 years
  • controlled blood pressure for at least 6 months

排除标准

  • major physical disability
  • medical treatment influencing metabolism
  • statin treatment
  • diagnosis or any sign of kidney disease

结局指标

主要结局

Muscle mass

时间窗: At baseline and post intervention (17th week)

次要结局

  • Relative strength(At baseline and post intervention (17th week))
  • Plasma creatinine(At baseline, mid (8th week) and post intervention (17th week))
  • Blood markers of fatty liver(At baseline and post intervention (17th week))
  • extracellular HSP72(At baseline and post intervention (17th week))
  • Blood markers of inflammation(At baseline and post intervention (17th week))
  • Plasma Lipid profile(At baseline and post intervention (17th week))

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

Loading locations...

相似试验