Influence of Tobacco Use on Cannabis Use
试验速览
- 阶段
- 2 期
- 状态
- 暂停
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Cannabis self-administration
研究概览
简要总结
Cannabis smokers who also smoke tobacco cigarettes have markedly higher rates of cannabis relapse relative to those who do not use tobacco. There is a clear need to develop and evaluate interventions for dual tobacco and cannabis users. The investigators of this study have previously shown that the co-use of tobacco cigarettes contributes to the maintenance of daily cannabis use, and that age of cigarette onset is a critical predictor of treatment outcome. Short-term tobacco cessation may suffice in altering cannabis relapse rates in later-onset cigarette smokers, while a longer period of tobacco cessation may be needed for earlier-onset smokers. In the current study, a human laboratory model will be utilized to determine whether cannabis relapse varies as a function of tobacco cessation duration and age of tobacco use onset.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Research staff will be blind to the age of tobacco onset condition.
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and non-pregnant females aged 18-60 years old
- •Use cannabis
- •Smoke tobacco cigarettes
- •Medically and psychologically healthy
排除标准
- •Regular drug use other than cannabis
- •Current pregnancy/lactation
研究组 & 干预措施
Early-onset Cigarette Smokers
Participants who began smoking cigarettes earlier in life (<16 years old) will be randomized to 7 or 21 days of tobacco cessation.
干预措施: 7 days of Tobacco Cessation (Behavioral)
Late-onset Cigarette Smokers
Participants who began smoking cigarettes later in life (>16 years old) will be randomized to 7 or 21 days of tobacco cessation.
干预措施: 7 days of Tobacco Cessation (Behavioral)
Early-onset Cigarette Smokers
Participants who began smoking cigarettes earlier in life (<16 years old) will be randomized to 7 or 21 days of tobacco cessation.
干预措施: Cannabis (Drug)
Late-onset Cigarette Smokers
Participants who began smoking cigarettes later in life (>16 years old) will be randomized to 7 or 21 days of tobacco cessation.
干预措施: Cannabis (Drug)
Early-onset Cigarette Smokers
Participants who began smoking cigarettes earlier in life (<16 years old) will be randomized to 7 or 21 days of tobacco cessation.
干预措施: 21 days of Tobacco Cessation (Behavioral)
Late-onset Cigarette Smokers
Participants who began smoking cigarettes later in life (>16 years old) will be randomized to 7 or 21 days of tobacco cessation.
干预措施: 21 days of Tobacco Cessation (Behavioral)
结局指标
主要结局
Cannabis self-administration
时间窗: During 9-day inpatient phase
Number of cannabis cigarettes participant chooses to smoke.
次要结局
未报告次要终点
研究者
Margaret Haney
Professor of Psychiatry, Columbia University
New York State Psychiatric Institute