Alcohol, Behavior, and Brain Imaging
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 80
- 主要终点
- Stop Signal Task (SST)
研究概览
简要总结
To evaluate the relationship of extraversion to both the acute subjective and behavioral effects of alcohol, and the neural reactivity to the anticipation of reward.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 29 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •21-29 years old
- •7-30 alcoholic drinks per week (as reported on PHQ or TLFB)
- •At least one binge episode (4 for females/5 for males) per month
- •No 'flushing' reaction to alcohol
- •Females must be on birth control or in the beginning of follicular phase (1-14 days after start of menstruation)
- •BMI 19-26
- •High school education or greater, fluent in English
- •No night shift work
- •No current or past year Axis I psychiatric disorder including drug/alcohol dependence
- •No current psychopharmacological treatment
- •No lifetime ADHD or prescription for ADHD medication
- •No abnormal EKG, cardiovascular illness, high blood pressure
- •No medical condition or pharmacological treatment for which alcohol is contraindicated
- •Not pregnant, lactating, or planning to become pregnant
- •Smoke <6 cigarettes per day
- •No previous participation in studies that have used the Stop Task (except IDAC) o Previous Stop Task studies: GOI, CAP, STEM, JAM, MACI, PAC, CAM
排除标准
- 未提供
研究组 & 干预措施
Ethanol
Subjects will receive 4 color-coded beverages in green or blue cups, containing ethanol (0.2 g/kg per dose, total dose 0.8 g/kg).
干预措施: Ethanol (Drug)
Placebo (Juice)
Subjects will receive 4 color-coded beverages in green or blue cups, containing placebo (Juice).
干预措施: Placebo (Other)
结局指标
主要结局
Stop Signal Task (SST)
时间窗: Within an hour post-stimulation condition
The Stop-Signal Task (SST) is a task requiring inhibition of a prepotent motor response. The SST requires participants to respond to a target stimulus as quickly and accurately as possible by pressing a button, but also to withhold their response when they hear an auditory signal. Thus, this task involves a competition between activating and inhibiting processes. The primary outcome variable is change in the stop signal reaction time (SSRT) for the task administered seconds to minutes before and seconds to minutes after stimulation. The theoretical minimum is zero seconds and there is no theoretical maximum. Higher SSRT scores reflect greater impulsivity.
次要结局
未报告次要终点