NCT06365775尚未招募不适用
Multi-omics Characteristics and Prognosis in Patients With Idiopathic Sudden Sensorineural Hearing Loss
Dan Bing0 个研究点目标入组 400 人开始时间: 2024年4月23日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 400
- 主要终点
- Pure tone audiometry (PTA)
研究概览
简要总结
The goal of this observational study is to describe the multi-omics characteristics and to learn about the prognostic factors in patients with idiopathic sudden sensorineural hearing loss (SSNHL). The main problems it aims to deal with are:
- if there is a difference in data of exome and targeted sequencing among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls
- if there is a difference in the parameter of MRI among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls
- to find out which factor from multi-omics data relates to outcomes of SSNHL
- to develop the best prognostics model based on the multi-omics data.
Participants will be received audiological tests, blood specimen collection and radiological examination. Researchers will explore the relationship between the multi-omics data and the prognosis and develop the predictive model.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants with SSNHL: unilateral or bilateral sensorineural hearing loss of > 30 dB HL (decibel) involving at least 3 continuous test frequencies developing within 72 hours
- •Healthy controls: people with PTA thresholds of all test frequencies ≤ 20 dB HL and without otologic disease in the last 3 months
- •Completed informed consent and promised to finish follow-ups
排除标准
- •Hearing loss with explicit causes, including noise-induced, Ménière's disease, ototoxicity exposure, mumps infection or history of syphilis infection and so on.
- •A history of head trauma or otologic surgery.
- •Malformation of temporal bone discovered by computed tomography (CT)
- •Retro-cochlear lesion discovered by magnetic resonance imaging (MRI)
- •Pregnant women
结局指标
主要结局
Pure tone audiometry (PTA)
时间窗: Baseline, 14 days, 1, 3 and 6 months follow-ups
Pure tone thresholds of 250, 500, 1000, 2000, 4000, 8000 Hz will be measured.
次要结局
- Speech reception thresholds(Baseline, 14 days, 1, 3 and 6 months follow-ups)
- Speech discrimination scores(Baseline, 14 days, 1, 3 and 6 months follow-ups)
研究者
Dan Bing
associate professor
Tongji Hospital
相似试验
尚未招募
不适用
Clinical Study on the Evaluation of the Efficacy of Cervical CancerUterine Cervical NeoplasmsNCT06254729First Affiliated Hospital Xi'an Jiaotong University4,000
已完成
不适用
Clinicopathological Characteristics and Prognosis Analysis of Stage IB Non-small Cell Lung CancerStage IB Non-Small Cell Lung CarcinomaNCT05979623Shanghai Zhongshan Hospital971
尚未招募
不适用
Prospective Multi-omics Observational Study of Gynecological Rare Pathological TumorsRare Gynecological TumorsMulti-omics AnalysisNCT05985941RenJi Hospital600
招募中
不适用
Assesment of Multiomics Profiles in Health and Disease.Genetic Predisposition to DiseaseNCT04427163The Institute of Molecular and Translational Medicine, Czech Republic1,100
已完成
不适用
Chronic Low Back Pain and Neck Pain Prospective StudyChronic Low Back PainChronic Neck PainNCT04883476The University of Hong Kong800