Acid Production in Dental Plaque After Exposure to Probiotic Bacteria
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Acid production in plaque after exposure to probiotic bacteria
研究概览
简要总结
The increasing interest in probiotic lactobacilli in health maintenance has raised the question of potential risks. One possible side effect could be an increased acidogenicity in dental plaque. The aim of this study was to investigate the effect of probiotic lactobacilli on plaque lactic acid (LA) production in vitro and in vivo.
Methods. subjects (n=18) were given lozenges with probiotic lactobacilli (L. reuteri DSM 17938 and ATCC PTA 5289) or placebo for two weeks in a double-blinded, randomized cross-over trial. The concentration of LA in supragingival plaque samples was determined at baseline and after 2 weeks. Salivary counts of mutans streptococci (MS) and lactobacilli were estimated with chair-side methods.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •moderate to high counts of salivary mutans streptococci (>104 CFU) as estimated with the Dentocult SM chair-side test,
- •no visible open caries lesions or periodontal disease,
排除标准
- •ingestion of probiotic bacteria within the last two months,
- •ingestion of antibiotics within the last two months
结局指标
主要结局
Acid production in plaque after exposure to probiotic bacteria
时间窗: 2 weeks
次要结局
- Acid producton in plaque after in vitro exposure to probiotic bacteria(1 hour)
研究者
Mette Kirstine Keller
Reasearch Associate
University of Copenhagen