Metabolic Responses to Breakfast Consumption Versus Omission in Adolescent Girls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Post-lunch area under the curve (AUC) for glucose.
研究概览
简要总结
Breakfast consumption (BC) is frequently associated with a healthy lifestyle, healthy body weight and favourable cardiometabolic health. Research from studies in adults suggests that breakfast skipping causes elevated plasma glucose and insulin concentrations after lunch. However, there is currently no evidence to suggest a similar metabolic response in adolescent girls, a population that frequently skips breakfast. The primary purpose of this study is to examine the effects of BC versus breakfast omission (BO) on metabolic responses after lunch in healthy adolescent girls.
详细描述
Breakfast consumption (BC) is habitually associated with a healthy lifestyle (e.g., diet and physical activity), reduced adiposity and favourable cardiometabolic health profiles in children, adolescents and adults. Experimental research in adults has shown that breakfast consumption reduces the glycaemic and insulinemic response to lunch when compared with breakfast omission; this has been termed 'the second meal effect'. Further, breakfast consumption may improve exercise performance and increase free-living physical activity energy expenditure in adults. Understanding the postprandial metabolic responses to BC and breakfast omission (BO) in adolescent girls is particularly important, as this population frequently skips breakfast and have low physical activity levels. Yet, adolescent girls may respond differently to adults due to their distinct metabolic profiles, and past research has not targeted this population. The primary aim of this research is to examine whether BC versus BO affects postprandial glycaemic and insulinemic responses to lunch in adolescent girls. Secondly, it aims to examine the lipaemic and substrate oxidation responses during rest, substrate oxidation during an exercise bout performed later in the day, and physical activity enjoyment during the exercise bout.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 11 Years 至 14 Years（Child）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Aged 11 to 14 years old
- •Healthy weight Body Mass Index centile (between the 3rd and 91st centile - Cole et al 2000)
排除标准
- •Allergies to the breakfast and lunch ingredients
- •Fitted with a pacemaker
- •Unable to walk
- •Health related issues that could be affected by participation in the study (e.g., uncontrolled exercise-induced asthma, diabetes, epilepsy)
结局指标
主要结局
Post-lunch area under the curve (AUC) for glucose.
时间窗: 2 hours
Net incremental AUC and total AUC for 2-hour period post lunch in each condition will be calculated for plasma glucose. Five finger prick blood samples will be taken at 15, 30, 60, 90 and 120 minutes post lunch.
Total trial area under the curve (AUC) for glucose.
时间窗: 5 hours
Net incremental AUC and total AUC for the 5-hour entire trial period in each condition will be calculated for plasma glucose. Finger prick blood samples will be taken at at 0 (baseline), 30, 60, 120 and 180 min after breakfast consumption or omission and at 15, 30, 60, 90 and 120 minutes after lunch consumption.
Post-lunch area under the curve (AUC) for insulin.
时间窗: 2 hours
Net incremental AUC and totral AUC for 2-hour period post lunch in each condition will be calculated for plasma insulin. Five finger prick blood samples will be taken at 15, 30, 60, 90 and 120 minutes post lunch.
Total trial area under the curve (AUC) for insulin.
时间窗: 5 hours
Net incremental AUC and total AUC for the 5-hour entire trial period in each condition will be calculated for plasma insulin. Finger prick blood samples will be taken at at 0 (baseline), 30, 60, 120 and 180 min after breakfast consumption or omission and at 15, 30, 60, 90 and 120 minutes after lunch consumption.
次要结局
- Maximum fat oxidation rate during exercise(During exercise (approximately 30 minutes))
- Physical activity enjoyment(Following exercise (approximately 5-10 minutes post))
- Post-lunch area under the curve (AUC) for triaclyglycerol(2 hour)
- Total trial resting substrate oxidation.(5 hours)
- Post-lunch resting substrate oxidation(2 hours)
- Total trial area under the curve (AUC) for triaclyglycerol(5 hours)
- Fatmax during exercise(During exercise (approximately 30 minutes))
研究者
Dr Rebecca Jones
Lecturer in Exercise Physiology
University of Bedfordshire