NCT01446068已完成早期 1 期
Comparison of Postprandial Inflammation in Lean and Obese Subjects
Agroscope Liebefeld-Posieux Research Station ALP4 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2011年3月1日最近更新:
适应症
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 4
- 主要终点
- Interleukin-6 (serum)
研究概览
简要总结
The purpose of this study is to quantify the systemic inflammatory and metabolic response of lean subjects and obese subjects to the ingestion of three caloric doses of a high-fat meal.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •for lean subjects:
- •* age 25-50
- •* 20\102cm
排除标准
- •for lean and obese subjects:
- •Physiological or psychological diseases
- •Allergies to food or intolerance to high-fat meal
- •Vegetarians
- •Chronic intake of drugs
- •Diabetes mellitus Type I and II
- •Debilitating kidney diseases
- •Debilitating liver diseases
- •Clinically established coronary heart diseases
- •Ingestion of vitamins or dietary supplements during the course of the study
结局指标
主要结局
Interleukin-6 (serum)
时间窗: 4h vs 0h
A statistically-significant increase in serum Interleukin-6 is expected at 4h compared to 0h
次要结局
- Glucose (serum)(0h, 1h, 2h, 4h, 6h)
- Triglyceride (serum)(0h, 1h, 2h, 4h, 6h)
- Insulin (serum)(0h, 1h, 2h, 4h, 6h)
- high sensitivity C-Reactive Protein(0h, 1h, 2h, 4h, 6h)
- HDL-cholesterol(0h, 1h, 2h, 4h, 6h)
- Total cholesterol(0h, 1h, 2h, 4h, 6h)
- Total cholesterol / HDL cholesterol(0h, 1h, 2h, 4h, 6h)
- Interleukin-6 (serum)(0h, 1h, 2h, 4h, 6h)
- Glucagon-like-protein-1 (serum)(0h, 1h 2h, 4h, 6h)
- Endotoxin (serum)(0h, 1h, 2h, 4h, 6h)
研究者
研究点 (4)
Loading locations...
相似试验
已完成
不适用
Investigation of the Postprandial Response of Two Different PDO Cheeses on Metabolic BiomarkersHealthyNCT05788887University of the Aegean10
已完成
不适用
Impact of Dairy Products on Postprandial InflammationInflammationNutritional InterventionObesityNCT01885416Agroscope Liebefeld-Posieux Research Station ALP21
已完成
不适用
Fat Quality and Postprandial InflammationInflammatory ResponseInflammationNCT05674708Göteborg University18
已完成
不适用
Diabetes and Metabolic Postprandial ResponsesOverweightType 2 DiabetesNCT00767208Centre de Recherche en Nutrition Humaine Rhone-Alpe24
招募中
不适用
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)Cardiac ArrestObesityNCT02664831MaineHealth400