Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Sublingual Microcirculatory Variables
研究概览
简要总结
Previous studies have demonstrated that altered microvascular blood flow is an important marker of severe sepsis. Usually, these patients need invasive ventilatory support, frequent use of sedatives and it is unknown if these agents interfere or not on microvascular blood flow. The goal of this study was to compare effects of propofol and midazolam infusions on sublingual microcirculation of septic shock patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Septic shock patients needing mechanical ventilation in pressure or volume-controlled mode.
排除标准
- •age less than 18 years,
- •pregnancy,
- •non-sinus rhythm, and
- •contraindication of daily interruption of sedative drug,
- •mainly with the use of neuromuscular blocking drugs, or
- •patients with intracranial hypertension or epileptical status.
结局指标
主要结局
Sublingual Microcirculatory Variables
时间窗: Just before stopping propofol and thirty minutes after the start of midazolam infusion
Patients were sedated with propofol during the first 24 hours after intubation and with midazolam afterwards.Systemic hemodynamics and perfusion parameters were assessed at two time points: just before stopping propofol and thirty minutes after the start of midazolam infusion. At both steps, four microcirculatory sequences were acquired using sidestream darkfield imaging to access sublingual microcirculation
次要结局
未报告次要终点
研究者
Guilherme Loures Penna
Principal Investigator
Casa de Saúde São José