The Optimized Diagnostic Methods for the Confirmation of Beta-lactam Hypersensitivity in Thailand
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity
研究概览
简要总结
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand. We hypothesize that only minority of patients with such a history are truly allergic.
详细描述
Patients with a history of beta-lactam hypersensitivity will be evaluated by the standard skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic if applicable), and intravenous forms of beta-lactam antibiotics .
Diagnostic values of the measurement of specific Immunoglobulin E to penicillin/aminopenicillin and skin test reagents currently available in Thailand will be comparatively analyzed with the standard skin test reagents.
The measurement of drug-induced interferon-gamma releasing cells will be measured in patients with a history of non-immediate reaction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 7 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with a history of beta-lactam hypersensitivity
排除标准
- •Being pregnant
- •Having serious medical illnesses
结局指标
主要结局
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity
时间窗: 1 year
The skin test positive rate in patients with a history of beta-lactam hypersensitivity
次要结局
- Clinical values of various diagnostic modalities in patients with a history of beta-lactam hypersensitivity(1 year)
研究者
Assoc. Prof. Jettanong Klaewsongkram, MD.
Associate Professor
Chulalongkorn University