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临床试验/NCT06661707
NCT06661707尚未招募不适用

Comparative Study Between Ultrasound Guided Quadratus Lumborum Versus Ilioingunial/ Iliohypogastric Nerves Block as Post-operative Analgesia for Patients Undergoing Inguinal Hernia Repair Surgeries

Ain Shams University0 个研究点目标入组 44 人开始时间: 2024年10月30日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
44
主要终点
The time to the first request of analgesia

研究概览

简要总结

Postoperative pain management is becoming an integral part of anesthesia care. Various techniques of pain relief have been designed. We have designed the study for comparison between ultrasound guided quadratus lumborum (QL) block versus Ultrasound-guided ilioinguinal and iliohypogastric nerves (ILI+IHG) block as regard postoperative pain block and opioid consumption in patients undergoing inguinal hernia repair under general anesthesia.

详细描述

In the anesthesia clinic, an informed written consent will be taken from every patient one day before the surgery. Explanation of the visual analogue score (VAS) will be performed. History, clinical examination and routine investigations including; complete blood count (CBC), fasting blood sugar (FBS), liver function test (LFT), kidney function test (KFT), electrocardiogram (ECG), prothrombin time (PT) and activated partial thromboplastin time (aPTT) will be performed to all patients.

In the induction room, an intravenous (IV) 20 gauge cannula will be inserted and premedication will be limited to intravenous (IV) midazolam (0.03 mg/kg).

  • Intra-operative setting:
  • General anesthesia technique:

The patient will be fasting for at least 8 hours preoperatively. A standardized general anesthesia protocol will be used for all patients. General anesthesia will be induced with propofol (1.5-2 mg /kg) and fentanyl (1 µg /kg) with neuromuscular block Atracurium (0.5mg/kg at induction then 0.1mg/kg as maintenance dose. The patient's airway will be maintained using an endotracheal tube. Maintenance of anesthesia will be commenced using isoflurane (1.2%) in a 50% mixture of oxygen in air.

Ventilator Settings: the ventilation will be achieved with a volume-controlled mode ventilation, respiratory rate adjusted according to EtCO2 to range between 30-35 mmHg, a tidal volume of 6-8 ml/kg and mixture of gases in proportion 50% oxygen and 50% air, with PEEP 5 cm H2O using a closed circle system with a total fresh gas flow rate of 3L/min.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Physical Status: ASA (American society of Anesthesiologists) I - II patients.
  • undergoing inguinal hernia repair

排除标准

  • Contraindications to QL block & ILI+IHG nerve block such as; (Infection at site of injection, allergy to local anesthetic drugs.)
  • Refusal of procedure or participation in the study by patients.
  • Psychiatric illness or uncooperative patient.
  • Coagulopathy, use of anticoagulants or antiplatelet therapy.
  • Chronic analgesic users, drug addicts and alcoholic patients.

结局指标

主要结局

The time to the first request of analgesia

时间窗: 24 hours postoperative

visual analogue score ≥3 by giving pethidine (50 mg IV)

次要结局

  • Total doses of analgesia(24 hours postoperative)
  • occurence of side effects(24 hours postoperative)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

RAMY AHMED

Assistant Professor of Anesthesia

Ain Shams University

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