Mitochondrial Remodeling After Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 2
- 主要终点
- Change in skeletal muscle mitochondrial protein degradation peptide products
研究概览
简要总结
Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-45 years
- •Body mass index (BMI) 18-45 kg/m2
- •Sedentary (<1 hour of planned exercise per week)
排除标准
- •Regular exercise (>1 hour of planned exercise per week)
- •Smoking, tobacco or nicotine use within the last 1-year
- •Fasting glucose >126mg/dL
- •Hypertension (systolic pressure >140 mmHg or diastolic pressure >90 mmHg)
- •Chronic metabolic or cardiovascular health conditions
- •Pregnant, nursing, irregular menses or post-menopausal
- •Lidocaine allergy
- •Certain medications
- •Physical limitations that prevent safe or successful exercise completion
- •Diminished capacity for consent
结局指标
主要结局
Change in skeletal muscle mitochondrial protein degradation peptide products
时间窗: After 2-weeks of exercise training compared with before training.
Skeletal muscle mitochondrial protein degradation peptide products after 2-weeks of exercise training compared with before training.
次要结局
未报告次要终点
研究者
Sean Newsom
Assistant Professor
Oregon State University