Incidence of Postoperative Residual Curarization in Elderly Patients in the Post-anesthesia Care Unit, and Attitude and Awareness Questionnaire of Anesthesiologists
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The incidence of postoperative residual curarization
研究概览
简要总结
In this study, we aimed to determine the knowledge levels and approaches of anesthesiologists working in our clinic about postoperative residual curarization(PORC) in elderly patients with a questionnaire. In addition, we aimed to determine the incidence of PORC and factors associated with PORC in the recovery unit in elderly patients over 65 years of age who underwent surgery under general anesthesia using muscle relaxants with a prospective observational study.
详细描述
Postoperative residual curarization (PORC) after general anesthesia is an important complication that can cause adverse patient outcomes, including symptoms of airway obstruction, hypoxia, respiratory distress, muscle weakness, and dyspnea in the early and late stages.
Anticholinesterase agents are commonly used to reverse neuromuscular blockade. Even with the use of anticholinesterase, severe PORC can be seen. The use of anticholinesterases in elderly patients is controversial due to the high side-effect profile.
Sugammadex, which has been widely used with its approval by the United States Food and Drug Administration in 2015, is a reverse agent that acts through a different mechanism than traditional anticholinesterase agents (it is a cyclodextrin molecule that encapsulates steroid neuromuscular blockers). Compared to neostigmine, sugammadex reverses neuromuscular blockade faster and more reliably.
In this study, we aimed to determine the knowledge levels and approaches of anesthesiologists working in our clinic about postoperative residual curarization(PORC) in elderly patients with a questionnaire. In addition, we aimed to determine the incidence of PORC and factors associated with PORC in the recovery unit in elderly patients over 65 years of age who underwent surgery under general anesthesia using muscle relaxants with a prospective observational study.
The first phase of the study is a prospective observational study. Elderly patients (>65) who are scheduled to undergo elective surgery under general anesthesia and require intubation using muscle relaxants will be screened for PORC using Train of four monitor in the recovery unit.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 95 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •general anesthesia using non-depolarizing neuromuscular blocker
排除标准
- •Patients with an ASA score greater than 3
- •Those with contraindications to anesthetic drugs
- •Those with neuromuscular, neurological and psychiatric diseases
- •Patients in whom TOF monitoring is not possible in the ulnar nerve region
- •Patients with advanced renal failure
- •Patients with advanced hepatic insufficiency
- •Those with decompensated heart failure
- •Patients with BMI<18 and BMI>30
- •Patients with uncontrolled hypertension, uncontrolled diabetes, pheochromocytoma, thyroid dysfunction
- •Those who are incapable of reading and signing the consent form
- •Patients who do not want to sign the consent form
- •Patients deemed unsuitable by the investigator
- •Those with chronic opioid use
结局指标
主要结局
The incidence of postoperative residual curarization
时间窗: through study completion( anticipated 5 months)
The incidence of elderly patients that Train of Four(TOF) rate \<0.9 in the postoperative care unit
次要结局
未报告次要终点
研究者
aysun postaci
Ass. Prof. Dr. Nadide Aysun Postaci
Ankara City Hospital Bilkent