跳至主要内容
临床试验/NCT07594691
NCT07594691招募中不适用

Inhale and Exhale Breath Holds to Improve the Therapeutic Ratio in Upper Abdominal Cancers Treated With SBRT

University Health Network, Toronto1 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2026年5月25日最近更新:
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
15
试验地点
1

研究概览

简要总结

This is a prospective quality improvement study. The INEX RT P study will prospectively evaluate INEX RT R that optimizes radiation dose delivery to the target while minimizing dose to critical organs at risk (OAR) by treating patients with different phases of breath hold (inhale and exhale) during the same course of SBRT. 15 patients with abdominal cancer whom are expected to achieve a dosimetric advantage from this technique due to OAR proximity to target will be treated using INEX RT. Investigators hypothesize increasing the dose to the RT target by at least 10% while simultaneously decreasing or maintaining dose to adjacent critical OARs when using a combination of breath hold positions to purposefully vary the position of OARs during different fractions of the same treatment course, when compared to RT treatments planned on a single breath hold phase alone (present standard of care).

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Any patient undergoing radiation therapy for a cancer lesion in the abdomen in close proximity to OARs that is hypothesized to have differential displacement on inhale and exhale breath hold CT scans of the OAR relative to the tumor.
  • Patients need at least 3 fractions of RT
  • Critical OARs are within 2 cm of luminal GI structures, chest wall, or previous radiation fields
  • Able to receive and understand verbal and written information regarding study and able to give written informed consent

排除标准

  • Inability to perform inhale or exhale breath holds during standard workflow CT simulation evaluation

研究组 & 干预措施

Imaging

Experimental

干预措施: Simulation and treatment imaging (Diagnostic Test)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

Loading locations...

相似试验