Central Sensitization in Chronic Whiplash Patients: Metabolite Concentrations in the Anterior Cingulate Cortex and Periacueductal Gray Matter
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 主要终点
- Metabolite concentrations
研究概览
简要总结
The purpose of this study is to determine whether the metabolite concentrations within the anterior cingulate cortex and periaqueductal gray matter predict the intensity and interference of neuropathic pain after the development of chronic whiplash syndrome.
详细描述
Persistent chronic pain is a common symptom of whiplash leading to reduced quality of life. Little information is available regarding changes in brain processing areas and change in central sensitization to noxious input during the chronic phase of whiplash. Metabolite concentrations in the anterior cingulate cortex and periaqueductal gray matter may be predictors of neuropathic pain and these changes may explain the development of central sensitization in people with chronic whiplash.
Until now, there is not any study that show this approach.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Whiplash syndrome
- •Chronic pain
- •Age between 18 to 65 years
- •4 months to 2 years after the whiplash syndrome
排除标准
- •Neurological disease
- •Claustrophobia
结局指标
主要结局
Metabolite concentrations
时间窗: Baseline at 0 min
The metabolite concentrations will be measured by magnetic resonance (spectroscopy)
Brief Pain Inventory
时间窗: Baseline at 0 min
Brief Pain Inventory (BPI), it is used to evaluate the subject's perception of pain severity and its interference.
Conditioned Pain Modulation
时间窗: Baseline at 0 min
Conditioned Pain Modulation will be measured by a Pathway system (Medoc Ltd)
Neurophatic Pain Symptoms Inventory
时间窗: Baseline at 0 min
Neurophatic Pain Symptoms Inventory (NPSI), it is used to detect paresthesia/dysaesthesia, evoked pain and paroxysmal pain.
Pain Catastrophizing Helplessness Subscale
时间窗: Baseline at 0 min
Pain Catastrophizing Helplessness Subscale it is used to assess the catastrophizing score
Neck Disability Index
时间窗: Baseline at 0 min
Neck Disability Index (NDI), it is used to assess the disability after whiplash syndrome
次要结局
未报告次要终点