Is Variation of Plasmatic Protein Concentration During Continuous Renal Replacement Therapy Predictive of Hypovolemia in Intensive Care Unit?
试验速览
- 阶段
- 不适用
- 入组人数
- 52
- 试验地点
- 2
- 主要终点
- plasmatic protein concentration variation
研究概览
简要总结
The aim of the study is to analyze if blood protein concentration variation during continuous renal replacement therapy (CRRT) with fluid removal can predict a decrease of 15 % of cardiac index in intensive care unit (ICU) patients. Blood protein concentration, clinical data describing hemodynamic status (providing data from Pulsion medical system PiCCO2 ® monitoring), including preload dependency evaluation with passive leg raising, are collected at different times: before initiation of fluid removal, and after the first episode of hypotension or one hour after initiation of fluid removal.
详细描述
The aim of the study is to analyze if blood protein concentration variation during continuous renal replacement therapy (CRRT) with fluid removal can predict a decrease of 15 % of cardiac index in intensive care unit (ICU) patients. Blood protein concentration, clinical data describing hemodynamic status (providing data from Pulsion medical system PiCCO2 ® monitoring), including preload dependency evaluation with passive leg raising, are collected at different times: before initiation of fluid removal, and after the first episode of hypotension or one hour after initiation of fluid removal.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •up to 18 years old
- •continuous renal replacement therapy
- •Suspicion of fluid overload
- •Prescription of fluid removal by the intensivist
- •PICCO2 monitoring
排除标准
- •pregnancy
- •intra abdominal hypertension
- •Moribund patient
- •Abdominal hypertension
结局指标
主要结局
plasmatic protein concentration variation
时间窗: 1 hour
Two sample of plasmatic protein before and after a fluid removal will be performed. The variation of the protein concentration (computed as the difference between final and baseline value divided by the baseline value expressed in %) will be the index test to diagnose a decrease of cardiac output of more than 15 % due to the fluid removal.
次要结局
- hemoconcentration evaluated with hemoglobin variation(1 hour)
- Plasmatic protein concentration in patient with preload dependency before fluid removal(1 hour)
- Central venous pressure (CVP)(1 hour)
- Global end diastolic volume (GEDV)(1 hour)
- Extravascular lung water (EVLW)(1 hour)
研究者
Matthias Jacquet-Lagrèze
Medical Doctor
Hopital Louis Pradel