The Comparison of Thick Split-thickness Skin Graft Versus Thin Split-thickness Skin Graft in the Reconstruction of the Donor Site
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- healing time of the donor sites
研究概览
简要总结
In clinical settings, split-thickness skin graft (STSG) remain the gold standard for covering large skin defects. However, STSGs usually bring complications to the donor sites. The study objective was to compare the efficacy of thick split-thickness skin graft versus thin split-thickness skin graft in the reconstruction of the donor site.
详细描述
All patients were randomly divided into two groups. For the patients in the thick STSG group, the surgeons harvested thick STSGs which were larger than recipient sites. The extra skin was punctured and stretched to cover the donor site (the novel technique). For the patients in the thin STSG group, the surgeons harvested thick STSGs of the size of recipient sites. Their donor sites were covered with thin STSGs which were harvested from other parts of the patients. The 36-item short form health survey (SF-36) scores, pain scores, pruritus scores, scar scores and rates of complications were compared between the two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients had skin defects at functional sites or joint sites.
- •Patients aged 20-80 years.
- •The lateral thighs were chosen as the donor sites.
排除标准
- •Patients who were unable to complete the follow-up.
- •Pregnant or nursing mothers were not included.
- •Patients had an alternative source of pain other than surgical sites.
- •Patients with organ dysfunctions (heart failure, respiratory failure, liver dysfunction, renal impairment or intestinal failure), or cancers.
- •Patients with autoimmune diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, Sjogren's syndrome, connective tissues disease or systemic vasculitis) were not included.
- •Patients who had medications (such as corticosteroids, immunosuppressive agents or chemotherapy) within six months were not included.
- •Other reasons.
结局指标
主要结局
healing time of the donor sites
时间窗: 2 months post surgery
The complete healing time of the donor sites was defined as the day when 100% epithelialization was achieved,
次要结局
- pains scores (Visual Analogue Scales)(on Day 1 and Day 7 postoperatively)
- pruritus scores(at 3 months and at 6 months post-surgery)
- scars scores ( Vancouver Scar Scales )(at 3 months and 6 months post-surgery)
- life quality (36-item short form health survey scores)(Prior to surgery or at 6 months post-surgery)
研究者
YinWu
attending doctor of Department of Burn and Plastic Surgery,Nanjing First Hospital
Nanjing First Hospital, Nanjing Medical University