Impact of Cholesterol Level on Long-term Angiographic Outcome of Coronary Artery Bypass Grafting
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Graft patency
研究概览
简要总结
This single-centre cross-sectional study aims to ascertain the impact of dyslipidemia on long-term graft patency after coronary artery bypass grafting (CABG).
详细描述
All consecutive patients who underwent CABG from 1st January 2007 to 31st December 2008 at the Prince of Wales Hospital were eligible for entry.
Graft patency will be determined by computed tomography coronary angiogram. The severity of stenosis will be classified by the Fitzgibbon classification system.
The levels of individual lipid profile subcomponents, namely LDL-C, high-density lipoprotein cholesterol (HDL-C), total cholesterol and triglycerides (TG) will be obtained. A plot of lipid profile subcomponent measurements against time will be compiled and the area under the curve is calculated to estimate gross exposure after CABG. Average lipid exposure is calculated by dividing the gross exposure by the number of days lapsed between the first and last lipid profile measurements.
The association between average cholesterol target attainment and graft patency will then be determined.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All consecutive patients on record who underwent coronary artery bypass graft surgery in 2007 and 2008
排除标准
- •Single vessel LIMA-LAD anastomosis only
- •Concomitant valve and aortic procedures
- •Concomitant repair of post-infarct ventricular septal rupture
- •Defaulted follow-up
- •Informed consent cannot be obtained
- •Intermediate to high risk for contrast nephropathy, defined as estimated glomerular filtration rate less than 45 ml/min/1.73m2 or serum creatinine level <1.5 mg/dL (based on American College of Radiology criteria for diagnostic computed tomography risk)
- •Pregnancy
结局指标
主要结局
Graft patency
时间窗: Immediately after CTCA
Graft patency as assessed by computed tomographic coronary angiogram, using Fitzgibbon classification
次要结局
- Actuarial cardiac events(Immediately after CTCA)
研究者
Randolph Wong
Prof. Randolph Wong Hung Leung
Chinese University of Hong Kong