NCT02677415Unknown不适用
Impact of General vs Local Anesthesia on Neurological Function in Patients With Acute Ischemic Stroke Undergoing Endovascular Treatment
Beijing Tiantan Hospital2 个研究点 分布在 1 个国家目标入组 640 人开始时间: 2016年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 640
- 试验地点
- 2
- 主要终点
- modified Rankin score
研究概览
简要总结
Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment. It is unknown whether there is a causal relationship in this observation. The investigators are performing a large randomised trial of general versus local anaesthesia to definitively answer the question of whether anaesthetic type alters perioperative outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with AIS scheduled to receive emergency endovascular treatment, older than 18; the onset time is within 12 hours.
排除标准
- •Radiological ambiguity concerning infarction and vessel occlusion.
- •Additional intracerebral hemorrhage.
- •Posterior circulation infraction.
- •Coma on admission (Glasgow coma score less than 8).
- •NIHSS less than 10 or more than
- •Severe agitation or seizures on admission.
- •Obvious loss of airway protective reflexes and/or vomiting on admission.
- •Being intubated before treatment on admission.
- •Known allergy to anesthetic or analgesic.
结局指标
主要结局
modified Rankin score
时间窗: post-procedural 30 days
次要结局
未报告次要终点
研究者
Yuming Peng
M.D., Ph.D.
Beijing Tiantan Hospital
研究点 (2)
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