The Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65-75 Years Old: A 12-Month RCT
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 155
- 试验地点
- 2
- 主要终点
- Cognitive Performance of Executive Function
研究概览
简要总结
Primary Objectives:
1. To ascertain whether a 12-month, twice-weekly or once-weekly resistance training (RT) program will significantly improve executive function in community-dwelling women aged 65 to 75 years old compared with a 12-month, twice-weekly stretch and relax (S & R) program (shame exercise). We will assess executive function by standard neuropsychological tests.
Secondary Objectives:
- To describe the neural mechanisms that underpin the observed changes in executive function associated with a 12-month, twice-weekly or once-weekly RT training (by using functional magnetic resonance imaging (fMRI)).
- To investigate whether RT-induced changes in executive function are independently associated with changes in physiological fall risk profile.
- To investigate the dose response of RT (resistance training) on bone health as measured by dual energy x-ray and peripheral quantitative computed tomography.
- To conduct a one-year follow-up after the formal cessation of the resistance training programs to determine the persisting effect of resistance training on cognitive performance, cortical plasticity, physiological falls risk, and bone health.
详细描述
Primary Research Question: Does resistance training (RT) significantly improve cognitive function, specifically executive function in older women with a Mini-Mental State Examination (MMSE) score equal to or greater than 24 (i.e., cognitively intact) compared with a stretch & relax (S & R; control) program?
Secondary Research Questions:
- Are changes in cortical activation associated with RT-induced changes in executive function?
- Are RT-induced improvements in executive function associated with lowered physiological fall risk?
- Is there a dose-response on bone health with RT (resistance training)?
RESEARCH PLAN:
Study Design: A 12-month, single-blinded, randomized controlled trial. Participants: 155 cognitively-intact (i.e., MMSE score > 24), right-handed, sedentary community-dwelling women, aged 65 to 75 years.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 65 Years 至 75 Years（Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Sedentary (less than twice weekly exercising) women aged 65-75 years old without conditions restricting them from exercising.
排除标准
- 未提供
研究组 & 干预措施
1
Twice weekly resistance training for 52 weeks.
干预措施: Exercise Training (Behavioral)
2
Once weekly resistance training for 52 weeks.
干预措施: Exercise training (Behavioral)
3
Twice weekly balance and tone training for 52 weeks.
干预措施: Exercise training (Behavioral)
结局指标
主要结局
Cognitive Performance of Executive Function
时间窗: 12 months
次要结局
- Functional MRI and physiological falls risk(12 months)
研究者
Teresa Liu-Ambrose
Principal Investigator
University of British Columbia