Potential Role of the Enteral Feeding Systems on Early Bacterial Gut Colonization of Preterm Infants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 主要终点
- Number of infants sharing bacterial strains with the milk received by each one
研究概览
简要总结
The aim of this study is to evaluate the potential role of the enteral feeding systems on the bacterial colonization of premature infants during their NICU admittance and its evolution after 2 years, which is the age when the infant's gut starts to contain an adult-like microbiota.
详细描述
First spontaneously evacuated meconium and fecal samples were collected by the medical staff of the Hospital weekly from the diapers of the infants during their stay at the Neonatal Intensive Care Unit.
To evaluate the potential role of the enteral feeding systems as a site for colonization by nosocomial bacteria, and, its impact on early gut colonization of preterm neonates, mother's own milk, donor milk and preterm formula samples were obtained after passing through the external part of the enteral feeding tubes and cultured.
Later, when the infants reached 2 years of age, parents were contacted by phone to provide an additional fecal sample if their infants had not taken antibiotics within the previous 2 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Hours 至 8 Hours（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •gestational age of less than 32 weeks or with birth weight of less than 1,200 g
排除标准
- •any malformation or suffering from any genetic metabolic disorder
结局指标
主要结局
Number of infants sharing bacterial strains with the milk received by each one
时间窗: two years
The meconium and fecal samples of the infants have been analysed microbiologically. In parallel, own's mother milk, donor milk and formula milk have been analyzed microbiologically after their pass through the nasogastric feeding tube. The bacterial strains isolated from fecal samples of each infant have been compared with the bacterial strains isolated from the milk that have received each of them.
次要结局
- Number of bacterial strains shared by each infant and the milk received.(two years)
研究者
Juan M. Rodríguez
Professor
Universidad Complutense de Madrid