The Oculocardiac Reflex Influenced at Different Levels of Brain Wave Monitoring
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 188
- 主要终点
- heart rate change
研究概览
简要总结
Oculocardiac reflex during routine strabismus surgery was prospectively observed in association with routine brain wave monitoring.
Providence Hospital institutional review board (IRB) approved this observational study without need for consent.
详细描述
Introduction
The oculocardiac reflex (OCR), bradycardia that occurs during strabismus surgery, is blocked by anticholinergics and enhanced by opioids and dexmedetomidine. Two recent studies suggest that deeper inhalational anesthesia monitored by bispectral index (BIS) protects against OCR; the investigators wondered if our data correlated similarly.
Methods: In an ongoing, prospective study of OCR elicited by 10-second, 200 gram square-wave traction on extraocular muscles (EOM) from 2009 to 2013, anesthetic depth was estimated in cohorts using either BIS or Narcotrend monitors. The depth of anesthesia was deliberately varied between first and second EOM tested.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Months 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •those receiving anticholinergic medications
结局指标
主要结局
heart rate change
时间窗: intraoperative 10 seconds
bradycardia with extra ocular muscle tension
次要结局
未报告次要终点