NCT03952793终止不适用
Development of the Organoids Technique From Metastases From Patients With Advanced Form of Prostate Cancer: Use in Basic Research
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 1
- 试验地点
- 2
- 主要终点
- Success rate of establishment of the organoid culture
研究概览
简要总结
The aim of the study is the development of the organoid culture technique from metastases from patients with advanced form of prostate cancer. Once the technique is set up, the organoid will serve to test several antitumor molecules.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Patient with metastatic prostate cancer
- •Patient having a biopsy programmed as part of his care.
- •Patient having a biopsy programmed as part of hiscare.
- •Patient with sufficient tumor volume after imaging data review by the radiologist to guarantee a sufficient quantity of material for the diagnosis of biopsy and additional material for the study.
- •INR <1.5; Platelets > 50000 / μL
排除标准
- •Patient under age of 18 years.
- •Patient under Plavix or Effient or Ticlid without possibility of suspension for 5 days, low molecular weight heparin without possibility of suspension of the dose before the intervention, or Fondaparinux without possibility of suspension, or ReoPro without possibility of suspension for 24h and aPTT <50s and ACT <150s, or Integrilin or Aggrastat or Argatroban without possibility of suspension 4 H before the intervention, or Angiomax without possibility of suspending 2H to 3H if CrCL> 50 mL / min or 3H to 5h if CrCL <50 mL / min before the intervention or and Pradaxa without possibility of suspension 2 to 3 days if CrCL> 50 mL / min or 3 to 5 days if CrCL <50 mL / min before the procedure
- •Patient under desmopressin acetate (DDAVP)
- •Patient with HIV or Hepatitis C positive or Hepatitis B infection, defined by either a detection of the HBs antigen or the presence of anti HBc antibodies without HBs antibody detectable.
结局指标
主要结局
Success rate of establishment of the organoid culture
时间窗: 15 days
The success rate is defined by the rate of successful cell culture. A Cell culture is successful when organoids grow from dividing cells
次要结局
- Cell proliferation Molecular and cellular on mechanisms of drugs responses(20 days)
- Drugs testing on organoid for cell viability(20 days)
- Cell Apoptosis Molecular and cellular mechanisms of drugs responses(20 days)
研究者
研究点 (2)
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