Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Muscle sympathetic nervous system activity
研究概览
简要总结
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Control - BMI<30, age 18-55
- •Hypertensive - BMI<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI>30, age 18-55 Obese-hypertensive- BMI>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring
排除标准
- •All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,
研究组 & 干预措施
Healthy Control
Healthy age matched controls with no history of cardiovascular disease and normal bodyweight
干预措施: Neuropeptide Y (Drug)
Hypertensive
Hypertensive adults who are not obese
干预措施: Neuropeptide Y (Drug)
Obese
Obese adults who are not hypertensive
干预措施: Neuropeptide Y (Drug)
Obese-hypertensive
Obese adults who are being treated for hypertension
干预措施: Neuropeptide Y (Drug)
结局指标
主要结局
Muscle sympathetic nervous system activity
时间窗: Acutely on the day of study
recording of sympathetic nervous system activity from the peroneal or radial nerve
Blood flow measured by doppler ultrasound
时间窗: Acutely on the day of study
brachial and femoral artery blood flow
次要结局
未报告次要终点
研究者
Christopher Hearon
Assistant Instructor
University of Texas Southwestern Medical Center