NCT06174636招募中不适用
Lung Overdistension and Abdominal Pressure Rise: an EIT Based Pilot Study
University of Padova2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2023年6月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Variation of lung volume distribution
研究概览
简要总结
The goal of this pilot interventional no-profit study is to evaluate airway pressure, esophageal pressure and variations in lung volume distribution with EIT in mechanically ventilated patients admitted to our UTI with respiratory failure after the application of an abdominal weight and resulting increase of intra-abdominal pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Invasive mechanical ventilation in acute respiratory failure (PaO2/FiO2 <300 mmHg)
- •Need of PEEP trial
- •Need of urinary catheter (used to measure IAP)
排除标准
- •Contraindication to EIT use
- •Pacemaker or other metal device in thoracic region
- •Contraindication to abdominal weight placement
- •Surgical or traumatic incision on the abdomen
- •Severe abdominal hypertension
- •Esophageal diseases that counterindicate naso-gastric tube placement
- •Severe hemodynamic instability (norepinephrine > 0.1 mcg/kg/min; dobutamine or dopamine > 5 mcg/kg/min; epinephrine every dosage)
- •Severe obesity (BMI > 35 kg/m2)
- •Need of > 7 kg weight to reach 5 mmHg IAP increase
结局指标
主要结局
Variation of lung volume distribution
时间窗: through study completion, an average of 1 year
TID %
Variation of airway pressure
时间窗: through study completion, an average of 1 year
cmH2O
Variation of esophageal pressure
时间窗: through study completion, an average of 1 year
cmH2O
次要结局
未报告次要终点
研究者
Paolo Persona
Medical Doctor, Principal Investigator
University of Padova
研究点 (2)
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