NCT06331572已完成不适用
Exploring Blood Plasma Metabolomics: Unraveling the Metabolic Landscape in Treatment-Resistant Adolescent Depression
First Affiliated Hospital of Chongqing Medical University1 个研究点 分布在 1 个国家目标入组 162 人开始时间: 2021年8月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 162
- 试验地点
- 1
- 主要终点
- 17 items Hamilton Depression Scale
研究概览
简要总结
This study contributes new evidence for the identification of adolescent TRD and sheds light on differing pathophysiologies by delineating distinct plasma metabolic profiles between adolescent TRD and FEDN-MDD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 12 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 12-18 years
- •Meet the diagnostic criteria for MDD according to the DSM-5
- •First-episode and drug-naive
- •HAMD-17 score > 17
- •Age 12-18 years
- •Meet the diagnostic criteria for MDD according to the DSM-5
- •HAMD-17 score > 13
- •Currently or previously taking a standard therapeutic dose of antidepressant for at least 6 weeks, and they had at least one historical failure to an antidepressant (reduction in depressive symptoms <50%)
- •age 12-18 years
- •HAMD-17 score < 7
- •HCs without a personal history of a mental illness or family history in a first-degree relative
排除标准
- •FEDN-MDD、TRD：
- •the presence or past history of severe medical, neurological or psychiatric disorders (other than MDD in patients)
- •anxiety comorbidity was not considered an exclusion criterion provided that MDD was the main diagnosis and the primary reason for seeking assistance
- •substance abuse, head trauma, or loss of consciousness
- •Chronic physical diseases that significantly affect peripheral metabolism or neurological function
- •Pregnant and lactating women
- •the presence or past history of severe medical, neurological or psychiatric disorders
- •substance abuse, head trauma, or loss of consciousness
- •Chronic physical diseases that significantly affect peripheral metabolism or neurological function
- •Pregnant and lactating women
结局指标
主要结局
17 items Hamilton Depression Scale
时间窗: baseline
The Hamilton Depression Scale assesses the level of depressive symptoms in patients
次要结局
- Hamilton Anxiety Scale(baseline)
研究者
Xinyu Zhou
professor
First Affiliated Hospital of Chongqing Medical University
研究点 (1)
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