Can Exercise Training Reduce the Frequency and Severity of Hot Flushes Associated With Breast Cancer Treatment?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Change in Thermoregulation
研究概览
简要总结
In brief, this study sets out to understand if exercise training can reduce the frequency and severity of hot flushes associated with breast cancer treatment.
详细描述
In detail, the aim of this research project is to investigate whether improving temperature control mechanisms including vascular function, with exercise training is beneficial in alleviating hot flushes in breast cancer patients and their associated quality of life symptoms. Participants will be recruited at least 3-months post breast cancer treatment (surgery, radio-therapy, chemotherapy). This time point has been chosen for this study to allow patients to fully engage in the exercise intervention following treatment. All participants will be asked to attend the laboratory at Liverpool John Moores University on 4 separate occasions; 2 visits pre- and 2 visits following the exercise intervention for data collection including measures of vascular health, physical activity, sedentary behaviour, and fitness. The investigators will also gain information on food intake and incidence of hot flushes across a 7-day period pre- and post the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Able to provide written informed consent
- •Pre-menopausal, Peri-menopausal or post-menopausal
- •>4 hot flushes per day
- •Treated with tamoxifen or aromatase inhibitor
排除标准
- •Uncontrolled or severe hypertension (blood pressure > 160/100 mm Hg)
- •Any previous injury preventing exercise
- •Type 1 or 2 diabetes
- •Anti-depressants
- •Currently undergoing chemotherapy or radiotherapy
- •Current smoker
- •Cannot readily read and understand English
结局指标
主要结局
Change in Thermoregulation
时间窗: Change from pre- to post- 16 week exercise intervention
Participants will wear a tube-lined suit that allows manipulation of skin temperature by heating the water passed through the tubes. Core temperature will be increased by 1 degree (monitored using a temperature pill) with sweat rate and skin temperature recordings taken at 5minute intervals across 1 hour of heating. Thermoregulation will be compared during this hour to that of the post-exercise intervention re-test.
Change in Skin Blood Flow
时间窗: Change from pre- to post- 16 week exercise intervention
The change in skin blood flow will be measured using laser Doppler probes at the forearm.
次要结局
- Change in Cerebral Blood Flow(Change from pre- to post- 16 week exercise intervention)
- Change in Vascular Structure(Change from pre- to post- 16 week exercise intervention)
- Change in Vascular Function(Change from pre- to post- 16 week exercise intervention)
研究者
Helen Jones
Professor of Cardiovascular Physiology
Liverpool John Moores University