Work of Breathing Under Extreme Hypercapnia Induced by Ventilation Insufficiency
试验速览
- 阶段
- 不适用
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- The length of breathing
研究概览
简要总结
The aim of the study is to investigate Work of Breathing of a person in simulated avalanche snow and consequent use of the measured data for judging which one of three simulated scenarios are alike while increasing hypercapnia in the simulated avalanche snow.
详细描述
The study is a part of a university diploma thesis aimed at studying physiological conditions and development of breathing parameters of a person breathing in the simulated avalanche snow. The Investigator is measuring Work of Breathing in three scenarios: a) 2L air pocket, b) 2L air pocket with resistance compensation and c) no air pocket. The investigator hypothesize that the Work of Breathing during compensation of air pocket will be alike with no air pocket scenario, thus proving significance of the resistance reduction for survival. The aim of the study is to investigate the effect of Work of Breathing on gas exchange in subjects breathing into the simulated avalanche snow scenarios.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy and fit volunteers, classified as The American Society of Anesthesiologists class I
- •without a smoking history
排除标准
- •Tiffeneau Index less than 0.70
- •any cardiovascular or respiratory condition
研究组 & 干预措施
Wet Perlite, 2L air pocket
Breathing in the simulated avalanche snow. Breathing into model of wet perlite with 2L air pocket
干预措施: extreme hypercapnia induced by ventilation insufficiency (Other)
Wet Perlite 2L air pocket with resistance compensation
Breathing in the simulated avalanche snow. Breathing into model of wet perlite 2L air pocket with resistance compensation
干预措施: extreme hypercapnia induced by ventilation insufficiency (Other)
Wet Perlite, no air pocket
Breathing in the simulated avalanche snow. Breathing into model of wet perlite with no air pocket
干预措施: extreme hypercapnia induced by ventilation insufficiency (Other)
结局指标
主要结局
The length of breathing
时间窗: Continuously within up to 7 minute interval from the beginning of the breathing experiment
Time to termination of the breathing experiment due to the decision of the tested subject, or determined by high end-tidal carbon dioxide value or by the order by the clinician assessing the health status of the subjects.
次要结局
未报告次要终点