Multimodal Neuroimaging to Predict Cognitive Resilience Against Sleep Loss
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Differences in the medial prefrontal cortex (MPFC) as measured by fMRI, DTI, and MRS
研究概览
简要总结
Resilience is the ability to cope effectively and adapt to a wide range of stressful environmental challenges. Sleep loss has been shown to reduce activity in the brain regions responsible for resilience. The ability to resist the effects of sleep loss appears to be a stable, trait-like quality. This study will attempt to predict individuals' trait-resistance to sleep loss based on their neurobiology.
详细描述
Resilience, the ability to cope effectively and adapt to a wide range of stressful environmental challenges, appears to be mediated extensively by the medial prefrontal cortex (MPFC). Sleep deprivation has been shown to reduce metabolic activity throughout the brain, particularly the MPFC. The ability to resist the effects of sleep loss appears to be a stable, trait-like phenomenon that is consistent across situations, suggesting that it may reflect an enduring quality of the underlying neurobiological system. The present study aims to identify the neural basis of resilience and effectively discriminate resistant from vulnerable individuals during an overnight sleep deprivation session. Specifically, the primary aims of this research are 1) to further our understanding of the role of the MPFC in resilience and 2) to develop a statistical prediction algorithm based on multimodal neuroimaging that will reliably discriminate between individuals who are resilient versus vulnerable to the cognitive impairing effects of sleep loss.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 20-45 years
- •Right handedness as assessed by the Edinburgh Handedness Inventory
- •For women: regular menstrual cycles (duration between 25 and 35 days with no more than 3 day variation between cycle)
排除标准
- •History of head injury with loss of consciousness or post-traumatic amnesia, or major neurological illness
- •Medical or neurologic condition that would confound interpretation of results, including alcohol or drug abuse/dependence in the past 6 months, neurological disorders including any history of seizures
- •History of cardiac problems
- •History of major depressive disorder or anxiety disorder
- •Lifetime history of psychotic disorder, including bipolar disorder, schizophrenia, or obsessive compulsive disorder
- •Other DSM-IV diagnosis that could affect interpretation of results
- •Mixed or left handedness
- •Abnormal visual acuity that cannot be corrected by contact lenses
- •Daily caffeine use exceeding 400 mg per day
- •History of smoking or tobacco use in the past year
- •Metal within the body, pregnancy, or other contraindication for MRI procedures
- •Use of drugs or medications that could affect functional neuroimaging results (e.g., fluoxetine, beta-blockers)
- •Psychotropic medication use within the past 6 weeks
结局指标
主要结局
Differences in the medial prefrontal cortex (MPFC) as measured by fMRI, DTI, and MRS
时间窗: Session 2 of study (1 week after enrollment)
It is hypothesized that, relative to vulnerable individuals, those who are highly resistant to the adverse effects of sleep loss on cognition will show: 1) increased gray matter volume in the MPFC, 2) greater white matter integrity as indicated by the Diffusion Tensor Imaging measure of fractional anisotropy (FA) values in the MPFC, 3) greater functional activation in MPFC during cognitively demanding tasks, 4) greater functional connectivity between MPFC and alerting regions of the midbrain and thalamus; and 5) different ratios of GABA and glutamate within the MPFC.
次要结局
- Psychomotor Vigilance Task (PVT)(At sleep deprivation session (2 weeks after enrollment))
研究者
William Killgore
Assistant Professor
Mclean Hospital