IRCT20181217042020N2招募中1 期
Evaluation of the efficacy of Tofacitinib in maintenance therapy of patients with ulcerative colitis
Digestive Disease Research Institute of Tehran University of Medical Sciences0 个研究点目标入组 40 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 no limit（—）
- 性别
- All
入选标准
- •Age> 18 years old
- •Known case of Ulcerative Colitis
- •Mayo score =6 in last 4 months
- •No clinical response or clinical remission (failed treatment) after ant TNF being used for at least 12- 14 weeks or Azathioporin used for at least 8-10 weeks
- •Unacceptable side effects after Corticostroid, Azathioprine, Mercaptopurine, Infliximab, or Adalimumab therapy
- •Being enrolled in phase 1 of study (induction therapy with Tofacitinib)
- •Clinical response to induction therapy ( 2 months treatment duration) with Tofacitinib
排除标准
- •Abnormal chest x ray
- •pregnant women or women who plan to become pregnant
- •Acute infection
- •GFR< 60 ml/ min
- •Known case of cancer
- •positive TB test (PPD/ or IGRA test)
- •Being positive for tests: HBV, HCV, HIV, CMV
研究者
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