Study of Community Based Dual Task and Aerobic Exercise Intervention on Cognition and Mobility in Older Adults Without Dementia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Global cognitive functioning
研究概览
简要总结
The investigators proposed research will establish whether combining aerobic exercise with cognitive challenges is feasible and effective in community dwelling older adults with early signs of cognitive impairment.
详细描述
To determine the effects of dual-task aerobic exercise training on community dwelling older adults with early signs of cognitive impairment. We will compare an exercise intervention (E-I) versus an exercise control (E-C) group. Each week, both groups will accumulate a minimum of 120 minutes of exercise (target 150 minutes) from community-based group classes (50 minutes of aerobic exercise) and also complete 45 minutes of beginner-level Square Stepping Exercise (SSE). The E-I group will also answer cognitively challenging questions while doing SSE (dual-task training). This study will determine whether a combined multiple modality (primary component being aerobic exercise) and dual-task exercise program is both feasible and effective for improving cognitive and mobility status, as well as vascular compliance, in older adults who may be at risk for cognitive and mobility decline.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male/Female 55-90 years old.
- •Montreal Cognitive Assessment score ≤27
- •Preserved Instrumental Activities of Daily Living (based on Lawton-Brody Instrumental Activities of Daily Living Sale)
排除标准
- •Dementia (i.e., Mini-Mental Examination score <24 or self-reported physician diagnosis)
- •Major Depression (>=16 on the Center for Epidemiologic Studies - Depression Scale combined with clinical judgment by primary study physician)
- •Other neurological or psychiatric disorders
- •Recent history of severe cardiovascular conditions
- •Significant orthopedic conditions
- •Have blood pressure >180/100 mmHg or <100/60 mmHg
- •Unable to comprehend questionnaire material/study procedures
结局指标
主要结局
Global cognitive functioning
时间窗: 26 weeks
Four standardized domain-specific composite scores were averaged to create this standardized global cognitive functioning score (incorporates executive function, processing speed, verbal learning and memory, and verbal fluency.
次要结局
- Global cognitive functioning(12 & 52 weeks)
- Executive Function/Mental Flexibility(12, 26, and 52 weeks)
- Processing Speed(12, 26 and 52 weeks)
- Verbal Learning and Memory(12, 26 and 52 weeks)
- Verbal Fluency(12, 26 and 52 weeks)
- Gait variability (step length) under dual-task conditions(12, 26 and 52 weeks)
- Gait variability (step length) under single-task conditions(12, 26 and 52 weeks)
- Gait speed under dual-task conditions(12, 26 and 52 weeks)
- Gait speed under single-task conditions(12, 26 and 52 weeks)
- Double support (seconds and % gait cycle time) under dual-task conditions(12, 26 and 52 weeks)
- Double support (seconds and % gait cycle time) under single-task conditions(12, 26 and 52 weeks)
- Step length under dual-task conditions(12, 26 and 52 weeks)
- Step length under single-task conditions(12, 26 and 52 weeks)
- Carotid artery compliance(12, 26 and 52 weeks)
- Carotid artery Intima-media thickness (IMT)(12, 26 and 52 weeks)
- Ambulatory systolic blood pressure(12, 26 and 52 weeks)
- Clinic systolic blood pressure(12, 26 and 52 weeks)
- Ambulatory diastolic blood pressure(12, 26 and 52 weeks)
- Clinic diastolic blood pressure(12, 26 and 52 weeks)
- Total balance score(12, 26, and 52 weeks)
- Total Falls Self-Efficacy score(12, 26, and 52 weeks)
研究者
Robert Petrella, MD
Principal Investigator
Parkwood Hospital, London, Ontario