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临床试验/NCT02886637
NCT02886637已完成不适用

Effects of Immune Function on Prognositic Outcome in Critical Ill Patients With Acinetobacter Baumannii Infection

Southeast University, China0 个研究点目标入组 40 人开始时间: 2015年7月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
40
主要终点
28 day mortality

研究概览

简要总结

The purpose of the present study is to evaluate the effects of immune function on prognositic outcome in critical ill patients with Acinetobacter baumannii infection.

详细描述

This is a single-center, observational study. Patients with Acinetobacter baumannii infection in the intensive care unit of Zhongda Hospital were enrolled. We recorded the data of age, ICU admission diagnosis, underlying diseases, APACHE II score and infection site. Body temperature, heart rate, white blood cell counts, procalcitonin, C-reactive protein, SOFA score and the level of CD4+, CD8+, Th1, Th2 and HLA-DR in the blood measured by flow cytometry on the D1, D3 and D7 were also recorded.We can get the results of the change of immune function of critical ill patients after Acinetobacter baumannii infection. After compare the patients who die of survive at 28 day after infection, we can get the results of the relationship between the immune function and the outcome. We also can calculate the effect immune function on prognositic mortality in patients with Acinetobacter baumannii infection.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
16 Years 至 80 Years(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients admitted to ICU
  • Infection with Acinetobacter baumannii
  • Agree to participate the study

排除标准

  • Age less than 16 years old or older than 80 years old
  • pregnancy
  • immunosuppression patients which include
  • therapy 0.5mg/kg/day of prednisoneover(equivalent dose of other glucocorticoids) for at least 1 month within recent 3 month
  • Cancer chemotherapy within recent 3 month
  • Receive immunosuppression treatment because of solid organ transplant or Autoimmune diseases
  • allogeneic bone marrow transplantation or allogeneic haematopoietic stem cell transplantation.
  • HIV infection

结局指标

主要结局

28 day mortality

时间窗: 28 day

次要结局

未报告次要终点

研究者

发起方
Southeast University, China
申办方类型
Other
责任方
Principal Investigator
主要研究者

Jianfeng Xie

Attending

Southeast University, China

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