Prognosis in Neurological Intensive Care Unit Patients (proNICU Cohort)

Charite University, Berlin, Germany1 site in 1 country46 target enrollmentJune 2012

ConditionsNeurological Diseases

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Neurological Diseases
Sponsor: Charite University, Berlin, Germany
Enrollment: 46
Locations: 1
Primary Endpoint: Predictive properties of immune parameters (IL6, IL10, mHLA-DR) for functional outcome one year after symptom onset
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study examines the prognostic properties of immune parameters, clinical scores, electrophysiological tests (eeg, ssep, emg, eng) and functional imaging for the prediction of functional outcome one year after treatment on a neurological intensive care unit.

Registry

clinicaltrials.gov

Start Date

June 2012

End Date

October 3, 2016

Last Updated

7 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Charite University, Berlin, Germany

Responsible Party

Principal Investigator

Andreas Meisel

Prof. Dr. med. Andreas Meisel

Charite University, Berlin, Germany

Eligibility Criteria

Inclusion Criteria

•severe neurological disease making treatment on a neurological intensive care unit necessary
•consent by the patient or the legal representative

Exclusion Criteria

•participation in an interventional trial

Outcomes

Primary Outcomes

Predictive properties of immune parameters (IL6, IL10, mHLA-DR) for functional outcome one year after symptom onset

Time Frame: one year after symptom onset

To evaluate of the predictive properties of immune parameters (IL6, IL10, mHLA-DR) for functional outcome one year after symptom onset

Secondary Outcomes

Predictive properties of immune parameters in the cerebrovascular fluid for functional outcome one year after symptom onset(one year after symptom onset)
To evaluate of the predictive properties of clinical scores for functional outcome one year after symptom onset(one year after symptom onset)
To evaluate of the predictive properties of conventional (DTI) and functional imaging (resting state) one year after symptom onset(one year after symptom onset)
To evaluate of the predictive properties of electrophysiological measurements one year after symptom onset(one year after symptom onset)
Quality of life and the occurence of depression and burnout syndrome in relatives(one year after symptom onset)
Transcriptome analyses(one year after symptom onset)
Quality of life and occurence of depression in patients one year after symptom onset(one year after symptom onset)