Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated by an OHCA.

• Conditions: Out-Of-Hospital Cardiac Arrest; Coma; Myocardial Infarction; Outcome, Fatal; Neurologic Dysfunction

• Registration Number: NCT04584463
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

This study evaluate the association of some in-ICU factors with the neurological prognosis of patients admitted for an out-of-hospital cardiac arrest due to a myocardial infarction.

Detailed Description

Pre-hospital factors associated with poor neurologic outcome are well known. Meanwhile, in-ICU factors for the first 24 hours may impact neurologic outcome.

This observational study aim to study the factors such as ECLS, NSE dosage, therapeutic hypotermia... and their association with neurologic outcome in patient with myocardial infarction due to instable coronaropathy complicated by an out-of-+hospital cardiac arrest.

This is designed to be a observationnal, prospective, multicentric national french study

Study Timeline

• Status Verified: 2020-10
• Study First Submitted: 2020-10-06
• Study First Submitted QC: 2020-10-06
• Last Update Submitted: 2020-10-06
• Study First Posted: 2020-10-14
• Last Update Posted: 2020-10-14
• Study Start: 2020-10-30
• Primary Completion: 2021-10-30
• Study Completion: 2021-11-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• aged of 18 years old or more
• non opposition of the patient, or his family if he is unable to consent, after loyal and comprehensive explanation
• patient admitted in ICU
• the reason for admission is a resurected out-of-hospital cardiac arrest
• the cause of the cardiac arrest is a type 1 myocardial infarction

Exclusion Criteria

• refractory cardiac arrest (no flow > 30 minutes in normothermia)
• in-hospital cardiac arrest
• pregnancy
• patient under juridic protection
• opposition of the patient, or of his family is he is unable to consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Neurologic outcome (CPC)	30 day from in-ICU admission	Cerebral Performance Category Scale to assess neurologic outcome 1-2 : good outcome 3-4-5 : bad outcome

Secondary Outcome Measures

Name	Time	Method
Neurologic outcome (Rankin)	30 day from in-ICU admission	Rankin score to assess neurologic outcome; * 0-1-2 good outcome; * 3-4-5 bad outcome
death	30 day form in-ICU admission	all-causes death