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临床试验/NCT05723393
NCT05723393已完成不适用

Sympatholytic Effect of High Thoracic Erector Spinae Plane Block

Keimyung University Dongsan Medical Center2 个研究点 分布在 1 个国家目标入组 47 人开始时间: 2023年2月13日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
47
试验地点
2
主要终点
Perfusion index ratio at 10 minutes

研究概览

简要总结

The primary endpoint of this study was to identify if erector spinae plane bloock (ESPB) demonstrates any sympatholytic effect.

The secondary endpoint of this study was to compare the changes of PI value between responders and non-responders.

详细描述

The erector spinae plane block (ESPB) is a less invasive, safer, and technically easy alternative procedure to conventional neuraxial anesthetic techniques. In contrast to common neuraxial techniques such as paravertebral and epidural injections, the ESPB targets an interfascial plane which is far from the spinal cord, root, and pleura. First applied to thoracic neuropathic pain, currently ESPB is being applied to postoperative pain control and includes variable clinical situations. In the abdomen and thoracic wall, thoracic ESPB can be applied for pain control after cardiac surgery, video-assisted thoracic surgery, laparoscopic cholecystectomy, and thoracotomy. Recently, favorable postoperative pain control after lumbar spinal or lower limb surgeries has been reported with lumbar ESPB. In addition, ESPB has also been used for chronic pain conditions in the upper and lower extremities. The perfusion index (PI) is a numerical value for the ratio between pulsatile and non-pulsatile blood flow measured by a special pulse oximeter. Although the special probe for PI measurement is relatively more expensive compared with ordinary pulse oximetery probes, its benefit as a marker of peripheral perfusion and as an idex for sympathetic stimulation have increased its use progressively.

ESPB can achieve analgesic effect by blocking the ventral and doramal ramus and possibly by diffusion into paravertebral space. In constrast to lumar region, thoracic paravertebral space is very close to the sympathetic chain. Therefore, sympatholytic effect might be achieved by thoracic ESPB. No previous study has demonstrated the sympatholytic effect of ESPB.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
20 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Complex regional pain syndrome
  • Post-thoracotomy pain syndrome
  • Cervical foraminal stenosis
  • Cervical disc herniation
  • Herpes zoster

排除标准

  • Coagulation abormality
  • Previous spine surgery
  • Allergy to local anesthetics

结局指标

主要结局

Perfusion index ratio at 10 minutes

时间窗: baseline, 10minutes after ESPB

Perfusion index ratio at 10 minutes

Perfusion index changes among 4 times period

时间窗: baseline, 10minutes after ESPB, 20 minutes after ESPB, 30 minutes after ESPB

Perfusion index changes after T2 ESPB among 4 times period

Numerical rating scale changes among 3 times period

时间窗: baseline, 30 minutes after ESPB, 2 weeks after ESPB

Numerical rating scale changes among 3 times period

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ji Hee Hong

Professor

Keimyung University Dongsan Medical Center

研究点 (2)

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