Erticality Perception - Effects of Prolonged Roll-tilt in Healthy Human Subjects
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- adjustment errors of the subjective visual/haptic/postural vertical in upright position after prolonged whole-body roll-tilt positions.
研究概览
简要总结
The long-term goal of this research is to advance the investigators knowledge of how the brain combines the information of multiple sensory systems coding for spatial oriention and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright. After prolonged roll-tilt, humans show a systematic bias in perceived direction towards the previous roll-tilted position (so-called "post-tilt bias"). This effect could either be related to adaptation to the roll-tilted position (shifting the "null" position) or it could be related to changes in torsional eye position due to prolonged static roll-tilt (ocular counter-roll). While in the first case a post-tilt bias is predicted independently of the experimental paradigm used, the second hypothesis predicts a post-tilt bias only if retinal cues are integrated. In order to evaluate these hypotheses, the investigators will assess perceived vertical using both vision-dependent and vision-independent paradigms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ages 18-65 years
- •informed consent
- •absence of
排除标准
- •Exclusion Criteria:
- •peripheral-vestibular deficit
- •disturbed consciousness
- •history of sensory deficits
- •visual field deficits
- •other neurological or systemic disorder which can cause dementia or cognitive dysfunction
- •intake of antidepressants, sedatives, or neuroleptics
- •pregnancy, unless excluded by a negative pregnancy test
- •known neck pain or status post neck trauma
研究组 & 干预措施
intervention arm
In each participant the investigators will assess verticality perception in whole-body upright position by use of the SVV, the SPV and the SHV after static roll-tilt at ±90deg over 5min. Measurements will be obtained on a motor-driven turntable and two different roll-tilt positions will be applied (±90°). A visual line (SVV), a rod (SHV) or the turntable itself will be adjusted to indicate perceived direction of vertical. A total of three measuring sessions, each lasting about 60 minutes are scheduled.
干预措施: presentation of visual and vestibular stimuli (Behavioral)
结局指标
主要结局
adjustment errors of the subjective visual/haptic/postural vertical in upright position after prolonged whole-body roll-tilt positions.
时间窗: 10 minutes (i.e. short-term adaptation)
the accuracy and precision of visual vertical adjustments after prolonged roll tilt are quantified.
次要结局
- changes in adjustment errors of the subjective visual vertical when providing an additional optokinetic stimulus(10 minutes (i.e. short-term adaptation))
- changes in adjustment errors of the subjective haptic vertical when providing an additional optokinetic stimulus(10 minutes (i.e. short-term adaptation))
- changes in adjustment errors of the subjective postural vertical when providing an additional optokinetic stimulus(10 minutes (i.e. short-term adaptation))