Effects of Acute Pain on Motor Learning in Young vs Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- Digit Span Forward Test
研究概览
简要总结
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its retention in older adults. The investigators hypothesize that acute pain impairs retention of locomotor learning in young and older adults and that in older adults, these deficits are worsened and are related to the degree of normal age-related cognitive decline.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Application of pain or no stimulus cannot be masked from participants, nor from outcomes assessors.
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-35 (YA group only) or 55-85 (OA group only) years old
- •Sex-matched to a participant in the OA group (YA group only)
- •Self-identifying as generally medically healthy
- •Able to read, write and speak English
- •Able to provide informed consent and attend all testing sessions
- •Willing to undergo the experimental pain or non-painful electrical stimulation, if selected
排除标准
- •Resting HR < 50 or > 100 bpm
- •Resting BP < 90/60 or > 140/95 mmHg (YA group only) or > 165/95 (OA group only)
- •Any history or current mental health condition, learning/developmental disability or cognitive impairment, including severe untreated ADD/ADHD, severe untreated anxiety, severe untreated depression, autism spectrum disorder, insomnia, mild cognitive impairment, etc.
- •Score on the MoCA <23
- •Score on the GAD-7 ≥ 10
- •Score on the PHQ-2 ≥ 2 and score on the PHQ-9 ≥ 10
- •Any current (within last 3 month) or chronic medical conditions, including any musculoskeletal, cardiovascular, endocrine, pulmonary, metabolic, psychiatric or neurological diagnosis that (for OA group only) affects activities of daily living or would confound testing or place the subject at risk by participating, such as a significant cardiovascular condition or event (e.g., heart attack < 3 months ago, uncontrolled atrial fibrillation, uncontrolled angina, or congestive heart failure, chronic obstructive pulmonary disorder, peripheral vascular disease)
- •Any impaired sensation or weakness in either lower extremity or in the area targeted for the stimulus
- •History of serious concussion or head injury, defined as a loss of consciousness for > 5 minutes and/or requiring medical treatment, or > 2 concussions over the lifespan
- •Any history of acute or chronic problems with balance, any dizziness, or > 1 fall in the last 12 months
- •Taking 4 or more medications (YA group only)
- •Currently or regularly using any analgesic medications, over-the-counter remedies, or any other treatment for the purposes of pain relief (i.e., baby aspirin for heart health permitted, etc.)
- •Any current or chronic pain condition during the last year, located anywhere in the body with a (OA group only) pain intensity of > 2/10
- •Allergy to capsaicin or hot peppers
- •Any skin lesion, breakage or irritation in the area targeted for the painful stimulus
- •Skin sensitivity to soaps/creams/perfumes or to heat
- •Poor circulation in the area targeted for the painful stimulus
- •Prior participation in a locomotor learning study in this lab within the last 2 years or prior participation in a study in this lab that included the cognitive testing battery within the last 2 years.
结局指标
主要结局
Digit Span Forward Test
时间窗: the change between baseline and during application of intervention
number of digits (numbers) that can be repeated back in the same order as they were presented
Motor Retention Magnitude
时间窗: 24 hours post learning (day 2)
degree to which the learned locomotor pattern has been remembered (in step length % change, normalized to the amount learned from day 1)
Motor Learning Magnitude
时间窗: immediately after learning (day 1)
degree to which the new locomotor pattern has been acquired (in step length % change)
Digit Span Backward Test
时间窗: the change between baseline and during application of intervention
number of digits (numbers) that can be repeated back in the reverse order from which they were presented
次要结局
未报告次要终点
研究者
Susanne M Morton
Associate Professor
University of Delaware