跳至主要内容
临床试验/CTRI/2024/02/062452
CTRI/2024/02/062452尚未招募不适用

The feasibility of non-invasive cardiac output monitoring in living donor right hepatectomy – A prospective study.

Roopa M N1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2024年2月15日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
24
试验地点
1
主要终点
To assess fluid administration.

研究概览

简要总结

Living donor liver transplantation (LDLT) is an established treatment modality for end-stage liver disease and it alleviates the shortage of cadaveric donor organs. Donor safety during the perioperative period is a major concern of LDLT. In general, hepatectomy causes a significant blood loss which is among the major causes of post-operative morbidity and mortality. Any strategy to reduce blood loss during hepatectomy is important and various surgical and anaesthetic methods have been reported. Although low central venous pressure technique can still be effective, it may not be advantageous concerning the safety of healthy donors undergoing hepatectomy. Emerging evidence suggests that stroke volume variation, a simple and useful index for fluid responsiveness and preload status in various clinical situations, can be applied as a guide for fluid management to reduce blood loss during living donor hepatectomy. Most hemodynamic monitors used widely now are invasive, which may cause complications and bring discomfort to the patients. NICOM is an application of biological reactor technology, monitoring cardiac output, cardiac index, stroke volume, stroke volume variability and other hemodynamic parameters by analysing electric pulses through the frequency change of chest.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • Living donor hepatectomy surgeries.

排除标准

  • Refusal to participate.
  • Left lobe hepatectomy.

结局指标

主要结局

To assess fluid administration.

时间窗: Perioperatively. At the end of surgery

次要结局

  • To assess blood loss & blood product administration. To assess lactate, kidney function & hemodynamic stability.(Perioperatively. At the end of surgery.)

研究者

发起方
Roopa M N
申办方类型
Other [Intramural funding]
责任方
Principal Investigator
主要研究者

Roopa M N

Aster CMI hospital

研究点 (1)

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