Effect of Prevacid on Prostaglandin Levels in the Gastric Mucosa of Patients With Stress Ulcer
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- the effect of Prevacid on prostaglandin levels at 8 weeks
研究概览
简要总结
The purpose of this study is to measure the prostaglandin levels in patients with stress ulcer and the effect of Prevacid on prostaglandin levels in patients with stress ulcer.
详细描述
The prostaglandin system plays an important role in the gastric mucosa to strengthen its resistance against injury. Critically ill patients are at greatest risk of developing stress-related gastric mucosal lesions. Although the levels of prostaglandins in gastric mucosa in patients with stressed animal has been studied, prostaglandin levels in the gastric mucosa in patients with stress ulcer have not been studied and the effect of Prevacid on prostaglandin levels in gastric mucosa from patients with stress ulcer is unknown.
We hypothesize that prostaglandin levels are low in the gastric mucosa in patients with stress ulcer, and Prevacid is an effective agents in increasing prostaglandin levels in the gastric mucosa in stress stress ulcer.
Comparison(s): The prostaglandin levels in patients who treated with Prevacid for stress ulcer, compared to the prostaglandin levels in patients who treated with H2 blocker for stress ulcer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients in ICU with documented gastric stress ulcer by endoscopic examination, including patients with H. Pylori infection;
- •Patients have no known ulcer within 8 weeks prior to be admitted to ICU;
- •Patients not on any PPI for 4 weeks prior to the study;
- •Patients or family be consented for the study.
排除标准
- •Patients have gastric ulcer within 8 weeks prior to be admitted to ICU;
- •Patients have gastric cancer confirmed by pathology;
- •Patients on one of the PPIs already;
- •Patients on any of the Non-steroidal Antiinflammatory Drugs.
研究组 & 干预措施
Prevacid
Effect of Prevacid at 8 weeks; EGD(esophagogastroduodenal endoscopy) at day 1 & EGD at 8 weeks
干预措施: Prevacid (Drug)
结局指标
主要结局
the effect of Prevacid on prostaglandin levels at 8 weeks
时间窗: 8 weeks
次要结局
- esophagogastroduodenal endoscopy(EGD) with biopsy at day 1; EGD with biopsy at 8 weeks(8 weeks)
研究者
Dr. Qiang Cai MD/PhD
Professor
Emory University