Factors That Influence Blood Vessel Regulation During Exercise in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Forearm blood flow
研究概览
简要总结
This study will examine two separate interventions: 1) the effects of ischemic preconditioning or 2) a high fat meal on the capacity of the brachial artery to overcome sympathetic activation and dilate during exercise (also known as functional sympatholysis). Participants will be asked to complete rhythmic handgrip exercise with and without the application of -20 mmHg lower body negative pressure to increase sympathetic activation. Doppler ultrasound will be used to continuously measure brachial artery blood flow. Participants will complete the handgrip exercise and lower body negative pressure before and after the applications of each interventions. Participants may elect to only complete one intervention rather than complete both protocols. Intervention one is active or control ischemic preconditioning. Intervention two is high or low fat meals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years or older
排除标准
- •History of smoking (tobacco or cannabis), defined as any smoking within the past 3 months
- •Diagnosed cardiovascular or metabolic disease(s)
- •Recent musculoskeletal injury handgrip exercise
- •Prescription of chronic medications other than oral contraceptives
- •History of hypertension or presence of arrhythmia
研究组 & 干预措施
High fat meal
干预措施: Low fat meal (Dietary Supplement)
Low fat meal
干预措施: High fat meal (Dietary Supplement)
Ischemic preconditioning control
干预措施: Ischemic preconditioning control (Procedure)
Ischemic preconditioning
干预措施: Ischemic preconditioning (Procedure)
结局指标
主要结局
Forearm blood flow
时间窗: 3 hours after active and control interventions (Diet intervention only)
Doppler ultrasound - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
Forearm vascular conductance
时间窗: 3 hours after active and control interventions (Diet intervention only)
Blood flow divided by blood pressure - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
Forearm blood flow
时间窗: Baseline - Immediately before active and control interventions
Doppler ultrasound - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
Forearm blood flow
时间窗: Immediately after active and control interventions (IPC only)
Doppler ultrasound - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
Forearm blood flow
时间窗: 1 hour after active and control interventions (Diet intervention only)
Doppler ultrasound - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
Forearm blood flow
时间窗: 2 hours after active and control interventions (Diet intervention only)
Doppler ultrasound - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
Forearm vascular conductance
时间窗: Baseline - Immediately before active and control interventions
Blood flow divided by blood pressure - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
Forearm vascular conductance
时间窗: Immediately after active and control interventions (IPC only)
Blood flow divided by blood pressure - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
Forearm vascular conductance
时间窗: 1 hour after active and control interventions (Diet intervention only)
Blood flow divided by blood pressure - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
Forearm vascular conductance
时间窗: 2 hours after active and control interventions (Diet intervention only)
Blood flow divided by blood pressure - tested at rest and during rhythmic handgrip exercise with and without lower body negative pressure
次要结局
- Heart rate(3 hours after active and control interventions (Diet intervention only))
- Blood pressure(3 hours after active and control interventions (Diet intervention only))
- Blood pressure(Baseline - Immediately before active and control interventions)
- Blood pressure(Immediately after active and control interventions (IPC only))
- Blood pressure(1 hour after active and control interventions (Diet intervention only))
- Blood pressure(2 hours after active and control interventions (Diet intervention only))
- Heart rate(Baseline - Immediately before active and control interventions)
- Heart rate(Immediately after active and control interventions (IPC only))
- Heart rate(1 hour after active and control interventions (Diet intervention only))
- Heart rate(2 hours after active and control interventions (Diet intervention only))
研究者
Philip Millar
Associate Professor
University of Guelph