Anorexia Nervosa and Brain in Adolescence
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 主要终点
- Neuroimaging
研究概览
简要总结
Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in adolescence.
详细描述
Anorexia nervosa is severe mental health problem with increased incidence rates in adolescence. Etiology of anorexia nervosa is still mostly unkonwn. Adolescence is also critical period of brain development.
Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in both acute and remission state of anorexia nervosa in adolescence.
Study group are young anorexia nervosa patients, and control group are healthy same-aged students.
Research methods include non-invasive brain imaging methods such as Transcranial Magnetic Stimulation (TMS), and Magnetic Resonance Imaging (MRI). Other research methods are assessment of body composition, laboratory tests, self-rated questionnaires and psychiatric interview.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 19 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Study group: 1) age 16-19 years, 2) BMI below 17.5, 3) diagnosis: anorexia nervosa or atypical anorexia nervosa 4) diagnosed within last two years. Inclusion criteria.
- •Control group : 1) age 16-19 years, 2) BMI over 19.0, 3) No lifetime obesity (BMI over 30) nor eating disorder.
排除标准
- •glucose metabolism disorder or any chronic medical disorder, or medicine with possible effects on neurotransmitters, 2) previous mental health problem (excluded anorexia nervosa or atypical anorexia nervosa in study group), 3) smoking, nicotine products, alcohol or any other substance abuse or dependence, 4) contraindication for used brain imaging method.
结局指标
主要结局
Neuroimaging
时间窗: Baseline and at 3 years' follow-up
Transcranial magnetic stimulation (TMS) combined with electroencephalogram (EEG)
次要结局
- Neuroimaging(Baseline and at 3 years' follow-up)
研究者
Virve Kekkonen
Specialist in adolescent psychiatry, clinical lecturer
Kuopio University Hospital