跳至主要内容
临床试验/NCT04536064
NCT04536064Enrolling By Invitation不适用

COMBINATION OF LYMPHATICO-VENULAR ANASTOMOSIS AND LIPOSUCTION TO TREAT CANCER-RELATED LYMPHEDEMA: RATIONALE FOR A REGIONAL APPROACH

University of Siena1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2021年2月22日最近更新:
适应症

试验速览

阶段
不适用
状态
Enrolling By Invitation
入组人数
24
试验地点
1
主要终点
Volume reduction of the limb

研究概览

简要总结

  • cooperation of an International team with many years of experience in surgical management of lymphedema
  • description of an effective surgical strategy to treat cancer-related lymphedema, a high incidence pathology
  • the combination of LVA and liposuction guarantees long lasting results

详细描述

Cancer-related lymphedema represents one of the major complications of cancer treatment, especially for breast and gynecologic cancers. Moreover, it has high impact on cancer survivors and healthcare systems. Lymphedema management still remains challenging. The better understanding of lymphedema physiopathology as well as the development of sophisticated surgical and diagnostic techniques have led to effective strategies to address lymphedema patients but, despite the considerable interest in international literature, no consensus exist.

The authors present a retrospective analysis of 24 consecutive patients affected by cancer-related lymphedema treated by the combination of LVA and liposuction in the same surgical session. Patients data regarding limb volume, lymphangitis rate and quality of life index were assessed before surgery and 1 year after surgery.

One year after surgery an average volume reduction of 37,9% was registered. Lymphangitis rate significantly decreased after surgery to 0.95 per year. Quality of life score improved.

CONCLUSIONS The combination of LVA and liposuction represents an effective strategy in treating patients with cancer-related lymphedema, ensuring a significant decrease in volume and reduction of lymphangitis rate as well as stable results in time. In addition, it appears to be minimally invasive and well tolerated by patients, since it can be performed under local anesthesia with low risk of complications.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Other

入排标准

性别
All
接受健康志愿者

入选标准

  • previous lymphadenectomy

排除标准

  • free from cancer related pathology

结局指标

主要结局

Volume reduction of the limb

时间窗: one year after surgery

mesurement of volume reduction

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Guido Gabriele

MD

University of Siena

研究点 (1)

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