CTRI/2023/01/048782招募中未知
Efficacy and safety of oral hydroxyurea on Bcl11 and Xmn1 expression levels in transfusion-dependent β-thalassaemia: a randomized double-blind controlled clinical trial.
Multidisciplinary Research Unit MR0 个研究点目标入组 0 人开始时间: 待定最近更新:
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Patients aged 6 years and above.
- •Patients with confirmed genotypes of homozygous/ compound heterozygous β-thalassaemia major or HbE β-thalassaemia.
- •Patients who required more than eight blood transfusions during the preceding 12 months.
排除标准
- •Sickle β-thalassaemia
- •Coexisting chronic liver disease
- •Coexisting chronic kidney disease
- •Coexisting viral hepatitis
- •Patients with contraindications for hydroxyurea (e.g., hypersensitivity, bone marrow depression, pregnancy and lactation)
- •Patients who are expecting to get pregnant during the next 12 months
- •Patients who have undergone bone marrow transplantation
- •Patients on immunosuppressant therapy
- •Baseline serum ferritin >5000 ng/mL
- •Baseline white cell count <4000/μL
- •Baseline platelet count <1 50 000/μL
- •Patients who were started on regular transfusions for a predetermined limited period
研究者
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